三维斑点追踪技术联合血浆NT-proBNP评价蒽环类药物对左心室功能的影响

Evaluation of the Effect of Anthracyclines on Left Ventricular Function by Three-dimensional Speckle Tracking Combined with Plasma NT-proBNP

目的探讨应用三维斑点追踪技术联合血浆NT-proBNP评价蒽环类药物对左心室功能的影响。方法选择58例确诊为乳腺癌患者,均以多柔比星或表柔比星治疗为主,分别在化疗前、化疗后3周、9周、18周行二维超声心动图及3D-STI检查,测量超声心动图参数、左心室各节段收缩期纵向(GLS)、径向(GRS)、环向应变(GCS)、整体面积(GAS)参数定量数据及血浆NT-proBNP检测。结果与化疗前对比,化疗后患者左心室GLS、GRS、GCS、GAS测量数值降低,并且随着蒽环类药物剂量、时间的累积,这些测量数值呈进行性下降(P<0.05);化疗后血浆NT-proBNP水平升高(P<0.05)。结论3D-STI联合血浆NT-proBNP检测,有助于早期发现蒽环类药物致乳腺癌患者的心肌损害。

Objective To evaluate the effect of anthracycline drugs on left ventricular function by three-dimensional dot tracking technique combined with NT proBNP.Method Fifty-eight cases of breast cancer were selected.The patients were treated with doxorubicin or epirubicin.Two dimensional echocardiography and 3D STI were performed before and after chemotherapy,respectively.The echocardiographic parameters,the longitudinal systolic phase(GLS),the diameter(GRS),the circumferential strain(GCS),the total area(GAS)parameters and NT prob were measured NP detection.Results Compared with the pre chemotherapy,the measurement values of GLS,GRS,GCS and GAS in the left ventricular of patients after chemotherapy decreased,and with the accumulation of anthracycline drugs dose and time,the measured values decreased progressively(P<0.05),and the level of NT proBNP in plasma increased after chemotherapy(P<0.05).Conclusion 3D STI combined with NT proBNP can help to detect myocardial damage in breast cancer patients with anthracycline drugs.