小剂量甲巯咪唑联合普萘洛尔治疗甲状腺功能亢进症的疗效

Efficacy of Low-dose Methimazole Combined with Propranolol in the Treatment of Hyperthyroidism

目的探究小剂甲巯咪唑联合普萘洛尔治疗甲状腺功能亢进症的临床疗效。方法随机选取本院收治的106例甲状腺功能亢进症患者,按数字表法分为53例对照组和53例试验组,对照组实施小剂量甲巯咪唑治疗,试验组实施小剂量甲巯咪唑联合普萘洛尔治疗,分析比较两组患者治疗前后促甲状腺激素(TSH)、甲状腺素(FT4)和三碘甲状腺原氨酸(FT3)水平的变化情况及临床疗效。结果治疗前,比较两组患者的TSH、FT4及FT3水平,无明显差异(P>0.05);和治疗前比,治疗后两组患者的FT4及FT3水平均明显下降,且试验组的下降幅度要大于对照组(P<0.05);而治疗后,两组患者的TSH水平没有差异(P>0.05)。试验组与对照组治疗总有效率依次是96.23%和77.36%,试验组明显高于对照组(P<0.05)。结论和单独实施小剂量甲巯咪唑治疗相比,对甲状腺功能亢进症患者实施小剂量甲巯咪唑联合普萘洛尔治疗,临床疗效更好,不仅能有效改善患者TSH、FT4及FT3等甲状腺功能指标,还能明显提升治疗的总有效率,可为以后的临床治疗提供可靠的参考依据。

Objective To explore the clinical efficacy of small dose of methimazole combined with propranolol in the treatment of hyperthyroidism.Methods A total of 106 patients with hyperthyroidism admitted to our hospital were randomly selected and divided into 53 control groups and 53 experimental groups according to the numerical table method.The control group was treated with low-dose methimazole while the experimental group was treated with low-dose methimazole combined with propranolol.The changes and clinical effects of thyroid stimulating hormone(TSH),thyroxine(FT4)and triiodothyronine(FT3)levels before and after treatment were analyzed and compared between the two groups.Results Before treatment,TSH,FT4 and FT3 levels of the two groups of patients were compared,with no significant difference(P>0.05).Compared with before treatment,the levels of FT4 and FT3 in the two groups decreased significantly after treatment,and the decrease in the experimental group was larger than that in the control group(P<0.05).After treatment,the TSH levels of the two groups had no difference(P>0.05).The total effective rates of the treatment in the experimental group and the control group were 96.23%and 77.36%respectively,and the experimental group was significantly higher than the control group(P<0.05).Conclusion Compared with low-dose methimazole alone,low-dose methimazole combined with propranolol for hyperthyroidism patients has a better clinical effect.It can not only effectively improve thyroid function indexes such as TSH,FT4 and FT3,but also significantly improve the total effective rate of treatment,which can provide reliable reference for future clinical treatment.