阿奇霉素序贯治疗成人社区获得性肺炎的效果探讨

Effect of Azithromycin on Sequential Treatment of Adult Community Acquired Pneumonia

目的探讨阿奇霉素序贯疗法在成人社区获得性肺炎(CAP)治疗中的临床效果。方法选择2016年9月至2018年9月收治的112例CAP成人患者为对象,以随机分配方式将其分为参照组与试验组各56例,其中,参照组使用加替沙星氯化钠注射液静脉滴注,继而使用替沙星片口服治疗,试验组使用阿奇霉素粉针剂静脉滴注,继而使用阿奇霉素片口服治疗,对比两组治疗后的临床效果情况。结果参照组的总有效率是76.79%,试验组的总有效率是80.36%,两组组间差异无统计学意义(P>0.05);参照组不良反应总发生率是17.86%,试验组不良反应总发生率是3.57%,两组组间差异有显著性(P<0.05);参照组培养出的细菌共12株,清除率为91.67%(11/12),试验组培养出的细菌共13株,清除率为92.31%(12/13),两组组间差异无统计学意义(P>0.05)。结论对CAP临床治疗采取阿奇霉素序贯治疗方法疗效显著,不良反应少,应用安全性比较高。

Objective To investigate the clinical effect of azithromycin sequential therapy in the treatment of adult community acquired pneumonia(CAP).Methods A total of 112 CAP adult patients admitted between September 2016 and September 2018 were enrolled.They were randomly assigned to a reference group and an experimental group of 56 patients.Among them,the reference group used gatifloxacin chloride.Intravenous infusion of sodium injection,followed by oral treatment with tifloxacin tablets,the experimental group was intravenously infused with azithromycin powder injection,followed by oral treatment with azithromycin tablets.Comparing the clinical effects of the two groups after treatment.Results After treatment,the total effective rate of the reference group was 76.79%,and the total effective rate of the experimental group was 80.36%.The experimental group was slightly higher than the reference group,but the difference between the groups was not statistically significant(P>0.05).The total incidence of adverse reactions was17.86%,and the total incidence of adverse reactions in the experimental group was3.57%.There was a statistically significant difference in the incidence of adverse reactions between the two groups(P<0.05).There were 12 bacteria in the reference group.The clearance rate was 91.67%(11/12),and 13 strains of bacteria were cultured in the experimental group.The clearance rate was 92.31%(12/13).There was no significant difference in the bacterial clearance between the two groups(P>0.05).Conclusion The sequential treatment of acumycin in CAP clinical treatment is effective,with few adverse reactions and high application safety.