帕罗西汀与奥氮平联合治疗抑郁症合并睡眠障碍患者的疗效及不良反应

Efficacy and Adverse Reactions of Paroxetine Combined with Olanzapine in the Treatment of Depression with Sleep Disorders

目的分析帕罗西汀与奥氮平联合治疗抑郁症合并睡眠障碍患者的疗效及不良反应。方法选取2019年2月至2020年5月本院收治的74例抑郁症合并睡眠障碍患者,根据入院单号、双号分为两组,每组37例,对照组采取单一帕罗西汀治疗方案,研究组则接受帕罗西汀联合奥氮平治疗方案,统计两组的治疗效果。结果研究组治疗总有效率为94.59%,高于对照组的75.68%,差异有统计学意义(P<0.05);研究组治疗后的PSQI评分、SDS评分较对照组更低(P<0.05);两组不良反应总发生率比较,差异无统计学意义(P>0.05)。结论应用帕罗西汀联合奥氮平治疗抑郁症合并睡眠障碍患者不仅可减轻患者的抑郁程度、临床症状,而且有助于改善患者的睡眠质量。

Objective To analyze the efficacy and adverse reactions of paroxetine combined with olanzapine in the treatment of patients with depression combined with sleep disorders.Methods A total of 74 patients with depression combined with sleep disorder admitted to our hospital from February 2019 to May 2020 were selected and divided into two groups according to the admission number and double number,with 37 cases in each group.The control group was treated with paroxetine alone,while the research group was treated with paroxetine combined with olanzapine,and the treatment effect of the two groups was analyzed.Results The total effective rate of the study group was 94.59%,higher than that of the control group(75.68%),the difference was statistically significant(P<0.05).PSQI score and SDS score in the study group were lower than those in the control group(P<0.05).There was no significant difference in the total incidence of ADR between the two groups(P<0.05).Conclusion Paroxetine combined with olanzapine in the treatment of depression patients with sleep disorders can not only reduce the degree of depression and clinical symptoms,but also help to improve the sleep quality of patients.