摘要
MoO_(2)纳米颗粒作为一种过渡金属氧化物,具有较强的LSPR效应。为了充分发挥其光热和拉曼增强作用,合成了MoO_(2)掺杂的聚多巴胺纳米材料,并在聚多巴胺粒子的表面原位还原上铂纳米颗粒得到最终的MoO_(2)@PDA@Pt杂化纳米粒子(MPDPs)。将具有等离子激元效应的MoO_(2)、PDA和Pt粒子集成到单元中,不仅有利于高效的光热转换,而且有利于SERS的信号增强。所制备的复合材料不仅表现出优异的SERS性能和产氧性能,还可作为无损光热治疗(PTT)的重要候选药物。因此,开发具有高光热转换效率的纳米材料在肿瘤的光热治疗中具有重要意义。
A MoO_(2) doped polydopamine(PDA)SERS nanoprobe has been designed as the bifunctional theranostic platform for SERS and photothermal therapy.In this theranostic system,the MoO_(2) nanoparticles were encapsulated into the PDA bioinert shell,with in situ synthesized Pt nanoparticles(PtNPs).MoO_(2) served as the SERS-active and photothermal substrate due to its built-in plasmon effect and NIR photothermal capacity,while the PDA coating endowed the nanoprobes with good stability and biocompatibility.The MoO_(2)@PDA@Pt nanoparticles(MPDPs)could be applied to targeted detection and SERS imaging and produced oxygen.Moreover,it showed good photothermal performance.The excellent properties of MPDPs would make it a potential tool for in situ diagnosis and noninvasive treatment of cancer cells.
作者
何鹏
韩文豪
毕成
牛淑妍
HE Peng;HAN Wenhao;BI Cheng;NIU Shuyan(College of Chemistry and Molecular Engineering,Qingdao University of Science and Technology,Qingdao 266042,China)
出处
《青岛科技大学学报（自然科学版）》
CAS
2021年第2期42-50,共9页
Journal of Qingdao University of Science and Technology:Natural Science Edition
基金
国家自然科学基金项目(21505082,21705086)
山东省高校科技计划项目(J16LC10).
