巩膜敷贴放射治疗后葡萄膜黑色素瘤的退行及其与预后的关系

Regression of uveal melanoma after episcleral plaque radiotherapy and its relationship with prognosis

葡萄膜黑色素瘤是成年人眼内最常见的恶性肿瘤。巩膜敷贴放射治疗是葡萄膜黑色素瘤临床保留眼球的主要治疗方式,能有效控制肿瘤生长,但放疗后肿瘤退行反应异质性明显。有研究提出巩膜敷贴放疗后肿瘤退行速度可作为巩膜敷贴放射治疗预后因素,退行速度越快预后越差。一些学者研究发现,肿瘤初始高度、3号染色体单体化、GEP分型与巩膜敷贴放疗后葡萄膜黑色素瘤肿瘤退行速度密切相关。

Uveal melanoma is the most common malignant tumor in eyes for adults,and episcleral plaque radiotherapy is the primary eye-conserving choice for uveal melanoma.Episcleral plaque radiotherapy can effectively control tumor growth,but tumor regression after radiotherapy has obvious heterogeneity.Some studies have suggested that the rate of postoperative tumor regression could be used as a prognostic factor for episcleral plaque radiotherapy,the faster the rate of tumor regression,the worse the prognosis of uveal melanoma.Some scholars have found that initial tumor thickness,chromosome 3 status and GEP typing are closely related to the tumor regression rate of uveal melanoma after episcleral plaque radiotherapy.