Genome engineering technologies in rabbits 被引量：1

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摘要 The rabbit has been recognized as a valuable model in various biomedical and biological research fields because of its intermediate size and phylogenetic proximity to primates.However,the technology for precise genome manipulations in rabbit has been stalled for decades,severely limiting its applications in biomedical research.Novel genome editing technologies,especially CRISPR/Cas9,have remarkably enhanced precise genome manipulation in rabbits,and shown their superiority and promise for generating rabbit models of human genetic diseases.In this review,we summarize the brief history of transgenic rabbit technology and the development of novel genome editing technologies in rabbits.

作者 Jun Song Jifeng Zhang Jie Xu Minerva Garcia-Barrio Y.Eugene Chen Dongshan Yang

机构地区 Center for Advanced Models for Translational Sciences and Therapeutics

出处《The Journal of Biomedical Research》 CAS CSCD 2021年第2期135-147,共13页 生物医学研究杂志（英文版）

关键词 RABBIT transgenic animal gene targeting genome editing base editing

分类号 Q789 [生物学—分子生物学]

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参考文献5

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2Dongshan Yang,Jie Xu,Tianqing Zhu,Jianglin Fan,Liangxue Lai,Jifeng Zhang,Y. Eugene Chen.Effective gene targeting in rabbits using RNA-guided Cas9 nucleases[J].Journal of Molecular Cell Biology,2014,8(1):97-99. 被引量：19
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2021年第2期

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