病原微生物、慢性炎症与前列腺癌

Relationship of pathogenic microorganisms and chronic inflammation with prostate cancer

前列腺癌是老年男性常见的恶性肿瘤,会对患者的身心健康产生严重的影响。目前,前列腺癌的发病机制仍不明确,可能与年龄、种族、饮食、感染和炎症等相关。近年来,越来越多的研究发现前列腺癌与病原微生物、慢性炎症存在关联,病原微生物导致肿瘤相关性炎症,并导致细胞基因组损伤和不稳定性增加,在细胞因子和氧化应激分子机制参与下进一步诱发突变等密切相关,本文就病原微生物、慢性炎症和前列腺癌关联性的研究进展作一综述。

Prostate cancer is a common malignant tumor in elderly men, which seriously affects the physical and mental health of the patients. The pathogenesis of prostate cancer is still unclear though thought of to be possibly associated with age, race, diet, infection and inflammation. In recent years, more and more studies have found a close correlation of prostate cancer to pathogenic microorganisms and chronic inflammation, and that pathogenic microorganisms cause increase genome damage and instability of the cells, and induce mutations with the involvement of cytokines and oxidative stress molecular mechanisms. This review summarizes the advances in the studies of the correlation of pathogenic microorganisms and chronic inflammation with prostate cancer.