摘要
缺氧是诱导勃起功能障碍(ED)的重要原因之一。缺氧性ED的发生、发展是神经、血管、内分泌及各类细胞因子等多种因素共同作用的结果。目前关于缺氧性ED机制的研究在阴茎海绵体微结构、重要信号通路、氧化应激、激素水平以及细胞自噬等方面取得了一定的进展,但仍尚未完全明确。本文综述了缺氧性ED机制的研究现状与进展,以期为缺氧性ED的后续研究提供一定依据和方向。
Hypoxia is one of the important pathophysiologic causes of ED, and the development and progression of hypoxia-induced ED can be attributed to multiple factors relating nerves, blood vessels, endocrine and various cytokines. The mechanisms of hypoxia-induced ED have not been fully clarified by now despite some advances achieved in the respects of corpus cavernosal microstructure, important signaling pathways, oxidative stress, hormone levels, autophagy and so on. This review focuses on the present status of and progress made in the studies of hypoxia-induced ED in order to provide some evidence and a direction for further researches.
作者
牛立盼
朱璐(综述)
阿地力江·伊明
刘凤霞(审校)
NIU Li-pan;ZHU Lu;ADILIJIANG Yiming;LIU Feng-xia(Department of Human Anatomy,School of Basic Medicine,Xinjiang Medical University,Urumqi,Xinjiang 830011,China)
出处
《中华男科学杂志》
CAS
CSCD
北大核心
2021年第1期75-80,共6页
National Journal of Andrology
基金
国家自然科学基金(81860781)
中国博士后科学基金(2015M582774XB)。
关键词
勃起功能障碍
缺氧
机制
研究进展
erectile dysfunction
hypoxia
mechanism
research progress