强力定眩片联合西酞普兰治疗持续性姿势-知觉性头晕的疗效观察

Clinical Observation of Qiangli Dingxuan Tablet(强力定眩片)Combined with Citalopram in Treatment of Persistent Posture-Perception Dizziness

目的探讨强力定眩片联合西酞普兰治疗持续性姿势-知觉性头晕的临床效果。方选取2016年4月—2018年4月医院收治的持续性姿势-知觉性头晕患者76例,根据随机数字表法分为两组,对照组37例采用西酞普兰治疗,观察组39例采用强力定眩片联合西酞普兰治疗。对比两组治疗前后眩晕残障量表(DHI)评分、头晕发作频次、头晕发作持续时间以及血流动力学指标。结果治疗后,观察组DHI-E评分(13.13±1.65)、DHI-P评分(12.32±1.75)、DHI-F评分(14.62±1.62)及DHI评分(40.40±3.24)均较对照组DHI-E评分(25.27±1.83)、DHI-P评分(18.46±1.94)、DHI-F评分(20.63±1.75)及DHI评分(67.43±2.47)均降低(P<0.05);观察组头晕发作频次(2.11±0.35)次、头晕发作持续时间(12.75±0.52)min明显较对照组头晕发作频次(3.63±0.52)次、头晕发作持续时间(23.28±4.47)min降低(P<0.05)。治疗后,左椎动脉血流速度(50.34±6.16)cm·s^(-1)、右椎动脉血流速度(48.55±5.88)cm·s^(-1)、基底动脉血流速度(49.63±5.22)cm·s^(-1)、高于对照组左椎动脉血流速度(45.22±4.25)cm·s^(-1)、右椎动脉血流速度(42.73±5.11)cm·s^(-1)、基底动脉血流速度(44.23±5.05)cm·s^(-1),阻力指数(0.45±0.03)低于对照组(0.53±0.04),差异有统计学意义(P<0.05)。结论强力定眩片联合西酞普兰治疗持续性姿势-知觉性头晕的临床效果较优,可改善患者的情绪、躯体、功能状态,缓解头晕症状,提升左椎动脉、右椎动脉、基底动脉血流速度、降低血管阻力。

Objective To investigate the clinical effect of Qiangli Dingxuan Tablet(强力定眩片)combined with citalopram in the treatment of persistent postural-perceptual dizziness.Method From April 2016 to April 2018,76 patients with persistent postural-perceptual dizziness were divided into two groups according to random number table.Thirty-seven patients in the control group were treated with citalopram,and 39 patients in the observation group were treated with Qiangli Dingxuan Tablet combined with citalopram.The scores of DHI,frequency of dizziness attacks,duration of dizziness attacks and hemodynamic indexes were compared between the two groups before and after treatment.Results After treatment,DHI-E score[(13.13±1.65)points],DHI-P score[(12.32±1.75)points],DHI-P score[(12.32±1.75)points],DHI-F score[(14.62±1.62)points]and DHI score[(40.40±3.24)points]in the observation group were significantly lower than those in the control group[DHI-E score(25.27±1.83)points,DHI-P score(18.46±1.94)points,DHI-P score(20.63±1.75)points,DHI-F score(20.63±1.75)points and DHI score(67.43±2.47)points].The dizziness attacks frequency[(2.11±0.35)times]and the dizziness attacks duration[(12.75±0.52)min]were significantly lower than those of the control group[dizziness attacks frequency(3.63±0.52)times and the dizziness attacks duration(23.28±4.47)min](P<0.05).After treatment,the blood flow velocities of left vertebral artery[(50.34±6.16)cm·s^(-1)],right vertebral artery[(48.55±5.88)cm·s^(-1)]and basilar artery blood flow velocity[(49.63±5.22)cm·s^(-1)]were higher than the control group’s blood flow velocities of left vertebral artery[(45.22±4.25)cm·s^(-1)],right vertebral artery[(42.73±5.11)cm·s^(-1)],basilar artery blood flow velocity[(44.23±5.05)cm·s^(-1)]and resistance index(0.45±0.03)was significantly lower than the control group’s resistance index(0.53±0.04)(P<0.05).Conclusion Qiangli Dingxuan Tablet combined with citalopram is effective in the treatment of persistent postural-perceptual dizziness,and can improve patients’emotional,physical and functional state,relieve dizziness symptoms,and increase the blood flow velocity of left vertebral artery,right vertebral artery and basilar artery.