乳腺硬化性淋巴细胞性小叶炎2例临床病理观察

Sclerosing lymphocytic lobularitis of breast:clinicopathologic features of two cases

目的探讨乳腺硬化性淋巴细胞性小叶炎(SLL)的临床病理特点、诊断。方法收集2例SLL的病例行HE及免疫组化染色,查阅患者的病历资料获得相关临床信息,并查阅文献进行分析总结。结果2例SLL均为女性。例1,患者67岁,例2,患者76岁,因乳房肿块就诊,均有糖尿病及高血压病史。镜下见乳腺组织萎缩伴小叶内及小叶周围大量淋巴细胞浸润,部分血管周围也可见淋巴细胞浸润,淋巴细胞无异型。间质见纤维胶原组织增生,可见上皮样肌纤维母细胞。结论SLL是一种少见的乳腺疾病,镜下以小叶周围炎症及间质纤维化为特点,临床容易误诊,准确诊断依赖于临床与病理的密切结合。

Objective To investigate the clinicopathologic features,diagnosis of 2 cases of sclerosing lymphocytic lobuartitis of breast.Methods The HE and IHC stains were collected in 2 cases of sclerosing lymphocyticlobuartitis of breast.The patients’medical records were examined to obtain the imformation about the pertinnet clinical findings,then the related literature was reviewed and summarized.Results All two patients were female,presented with breast masses.Patient A was 67 years old,Patient B was 76 years old,both of them had a history of diabetes and hypertension.Microscopically,the atrophy of breast tissue was accompanied by infiltration of a large number of lymphocytes in and around the lobules,and infiltration of lymphocytes was also found around some blood vessels.There was no abnormal lymphocyte.Fibrocollagen tissue was hyperplasia and epithelioid myofibroblasts were seen in the stroma.Conclusions SLL is a rare breast disease.Microscopically,it is characterized by perilobular inflammation and interstitial fibrosis.It is easy to misdiagnose in clinic,and the accurate diagnosis depends on the close combination of clinic and pathology.