一个控制超强电离辐射抗性开关基因的研究进展

Research Progress of a Switch Gene in Response to Extreme Ionizing Radiation

电离辐射广泛存在于地球和空间,会引起生物体内的DNA损伤,导致机体突变甚至死亡.生物体的DNA损伤响应对于稳定基因组的完整性至关重要.耐辐射奇球菌因其超强的DNA修复能力成为研究DNA损伤修复的模式生物之一.PprI-DdrO系统是近年来发现的一种新型且高效的损伤响应途径,PprI作为响应损伤的重要开关蛋白,通过酶切DdrO调控DNA损伤响应基因的表达.本文从功能、结构、激活机制和潜在应用价值几方面描述了PprI的研究进展.

Ionizing radiation exists widely in Earth and space,causing DNA damage and leading to mutation and even cell death.DNA damage response is essential for maintaining the integrity of genome.Deinococcus radiodurans is one of the model organisms for studying DNA damage repair due to its extraordinary DNA repair ability.PprI-DdrO system is a distinct and efficient damage response pathway in Deinococcus,in which PprI acts as an important switch regulating DNA damage response genes by cleavage of DdrO.This review discusses the research progresses of PprI from aspects of function,structure,activation mechanisms and applications.