Biomimetic Au nanodot synthesis using Escherichia coli secretion and interaction with α-ketoglutaric acid

Dear Editor,Gold nanostructures have distinctive physicochemical properties,such as quantum size effects,surface plasmon resonance(SPR),high catalytic activity,and self-assembly,so they are one of the most widely studied materials.Over the past few years,researchers have increasingly focused on a diverse range of biomedical applications of gold nanoparticles(AuNPs)for photothermal and targeted drug delivery treatment for cancer and as biodiagnostic probes(Rao and Cheetham,2001).However,conventional AuNP chemosynthesis involves hazardous chemicals and has a high cost.In addition,a lack of excellent monodispersion,water dispersibility,and biocompatibility limit applications in biology and medicine(Kumar et al.,2008).Therefore,a green chemistry strategy for fabricating eco-friendly,nontoxic,cost-effective AuNPs with good biocompatibility and functionality is required.