基于伏邪理论探讨慢性阻塞性肺疾病气道重塑

Discussion on airway remodeling of chronic obstructive pulmonary disease based on the hidden pathogen theory

气道重塑是慢性阻塞性肺疾病患者气流受限的病理基础,并对肺功能造成持续性损害,尽早干预气道重塑是防治慢性阻塞性肺疾病及其并发症的关键所在。文章从伏邪理论着手,认为气道重塑类似于伏邪在体内伏匿的过程。脏腑功能失衡,气机乖戾是伏邪产生的基础,痰浊、瘀血是伏邪的主要组成部分,肺络是伏邪主要伏藏部位,而肺络受损是伏邪致病的直接后果。文章将从中医学伏邪相关理论对气道重塑进行阐述。

Airway remodeling is the pathological basis of airflow restriction in chronic obstructive pulmonary disease(COPD) patients, and causes persistent damage to pulmonary function. Early intervention of airway remodeling is the key to prevent and treat COPD and its complications. Based on the theory of ‘hidden pathogen’, this paper holds that airway remodeling is similar to the process of hidden pathogen concealment in the body. The imbalance of viscera function and abnormal qi mechanism are the basis for the generation of hidden pathogen. The main components of hidden pathogen is phlegm-turbidity and stasis blood. Lung collaterals are the main place of hidden pathogen stagnation, while lung collaterals damage is the direct consequence of the disease. This paper elaborates COPD airway remodeling from the hidden pathogen theory.