基于电子鼻的热证常见病位的口腔呼气气味图谱特征

Characteristics of odor response pattern oral exhalation among common disease locations of heat syndrome based on electronic nose

目的:探讨基于电子鼻的热证常见病位的口腔呼气气味图谱特征,为嗅诊客观化提供基础研究,为热证的诊疗提供参考依据。方法:收集284例热证患者的四诊信息,采用证素辨证的方法分析热证常见病位分布特点,同时运用电子鼻采集口腔呼气的气味图谱,选取气味图谱响应曲线的振幅和斜率作为图谱特征参数,研究热证常见病位的口腔呼气气味图谱特征。结果:热证患者的常见病位为胃、肺、脾+胃、肝。振幅特征:胃组气味图谱响应曲线A、C、D、F、G、H、I的振幅显著高于肺组(P<0.01);肺组气味图谱响应曲线A、C、D、F、G、H、I的振幅显著低于脾+胃组(P<0.01,P<0.05);肺组气味图谱响应曲线A、D、G、H的振幅显著低于肝组(P<0.01,P<0.05)。斜率特征:胃组气味图谱响应曲线A、B、C、D、F、G、H、I的斜率显著高于肺组(P<0.01,P<0.05),胃组气味图谱响应曲线H的斜率高于肝组(P<0.05);肺组气味图谱响应曲线A、B、C、D、F、G、H、I的斜率显著低于脾+胃组(P<0.01),肺组气味图谱响应曲线A、C、D、G、H的斜率低于肝组(P<0.05)。结论:运用电子鼻可以区分热证不同病位的口腔呼气气味特征,为热证的临床诊断提供参考。

Objective: To explore the characteristics of odor response pattern of oral exhalation among common disease locations of heat syndrome based on electronic nose, and to provide basic research for the objectification of olfactory diagnosis and provide reference for the diagnosis and treatment of heat syndrome. Methods: Four diagnostic information of 284 patients with heat syndrome were collected. The characteristics of common disease locations of heat syndrome were analyzed by the method of syndrome elements differentiation. At the same time, the odor response pattern of oral exhalation was collected by electronic nose, and the amplitude and slope of the response curve of odor map were selected as the characteristic parameters of the map to investigate the odor response pattern of oral exhalation among the common disease locations of heat syndrome. Results: The common disease locations of heat syndrome were stomach, lung, spleen + stomach and liver. Amplitude characteristics: the amplitude of response curves A, C, D, F, G, H, I in the gastric group was significantly higher than those in the lung group(P<0.01);the amplitudes of map response curves A, C, D, F, G, H, I in the lung group were significantly lower than those in the spleen + stomach group(P<0.01, P<0.05);the amplitudes of map response curves A, D, G, H in the lung group were significantly lower than those in the liver group(P<0.01, P<0.05). Slope characteristics: The slopes of response curves A, B, C, D, F, G, H, I in the gastric group were significantly higher than those in the lung group(P<0.01, P<0.05), and the slope of curve H in the gastric group was higher than that in the liver group;the slopes of map response curves A, B, C, D, F, G, H, I in the lung group were significantly lower than those in the spleen + stomach group(P<0.01), and the slopes of curves A, C, D, G, and H were lower than those in liver group(P<0.05). Conclusion: The odor characteristics of oral exhalation among different disease locations of heat syndrome can be distinguished by the electronic nose, which can offer a reference for clinical diagnosis of heat syndrome.