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基于电子鼻的热证常见病位的口腔呼气气味图谱特征 被引量:3

Characteristics of odor response pattern oral exhalation among common disease locations of heat syndrome based on electronic nose
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摘要 目的:探讨基于电子鼻的热证常见病位的口腔呼气气味图谱特征,为嗅诊客观化提供基础研究,为热证的诊疗提供参考依据。方法:收集284例热证患者的四诊信息,采用证素辨证的方法分析热证常见病位分布特点,同时运用电子鼻采集口腔呼气的气味图谱,选取气味图谱响应曲线的振幅和斜率作为图谱特征参数,研究热证常见病位的口腔呼气气味图谱特征。结果:热证患者的常见病位为胃、肺、脾+胃、肝。振幅特征:胃组气味图谱响应曲线A、C、D、F、G、H、I的振幅显著高于肺组(P<0.01);肺组气味图谱响应曲线A、C、D、F、G、H、I的振幅显著低于脾+胃组(P<0.01,P<0.05);肺组气味图谱响应曲线A、D、G、H的振幅显著低于肝组(P<0.01,P<0.05)。斜率特征:胃组气味图谱响应曲线A、B、C、D、F、G、H、I的斜率显著高于肺组(P<0.01,P<0.05),胃组气味图谱响应曲线H的斜率高于肝组(P<0.05);肺组气味图谱响应曲线A、B、C、D、F、G、H、I的斜率显著低于脾+胃组(P<0.01),肺组气味图谱响应曲线A、C、D、G、H的斜率低于肝组(P<0.05)。结论:运用电子鼻可以区分热证不同病位的口腔呼气气味特征,为热证的临床诊断提供参考。 Objective: To explore the characteristics of odor response pattern of oral exhalation among common disease locations of heat syndrome based on electronic nose, and to provide basic research for the objectification of olfactory diagnosis and provide reference for the diagnosis and treatment of heat syndrome. Methods: Four diagnostic information of 284 patients with heat syndrome were collected. The characteristics of common disease locations of heat syndrome were analyzed by the method of syndrome elements differentiation. At the same time, the odor response pattern of oral exhalation was collected by electronic nose, and the amplitude and slope of the response curve of odor map were selected as the characteristic parameters of the map to investigate the odor response pattern of oral exhalation among the common disease locations of heat syndrome. Results: The common disease locations of heat syndrome were stomach, lung, spleen + stomach and liver. Amplitude characteristics: the amplitude of response curves A, C, D, F, G, H, I in the gastric group was significantly higher than those in the lung group(P<0.01);the amplitudes of map response curves A, C, D, F, G, H, I in the lung group were significantly lower than those in the spleen + stomach group(P<0.01, P<0.05);the amplitudes of map response curves A, D, G, H in the lung group were significantly lower than those in the liver group(P<0.01, P<0.05). Slope characteristics: The slopes of response curves A, B, C, D, F, G, H, I in the gastric group were significantly higher than those in the lung group(P<0.01, P<0.05), and the slope of curve H in the gastric group was higher than that in the liver group;the slopes of map response curves A, B, C, D, F, G, H, I in the lung group were significantly lower than those in the spleen + stomach group(P<0.01), and the slopes of curves A, C, D, G, and H were lower than those in liver group(P<0.05). Conclusion: The odor characteristics of oral exhalation among different disease locations of heat syndrome can be distinguished by the electronic nose, which can offer a reference for clinical diagnosis of heat syndrome.
作者 林雪娟 吴敏 连梨梨 黄伟荣 王永发 周福 LIN Xue-juan;WU Min;LIAN Li-li;HUANG Wei-rong;WANG Yong-fa;ZHOU Fu(Research Base of TCM Syndrome,Fujian University of Traditional Chinese Medicine,Fuzhou 350122,China;Key Laboratory of TCM Health Status Identification of Fujian Province,Fujian University of Traditional Chinese Medicine,Fuzhou 350122,China;Fujian Provincial Collaborative Innovation Center for 2011 Chinese Medicine Health Management,Fuzhou 350122,China;Jinjiang Hospital of Traditional Chinese Medicine Affiliated to Fujian University of Traditional Chinese Medicine,Jinjiang 362200,China)
出处 《中华中医药杂志》 CAS CSCD 北大核心 2020年第12期6294-6297,共4页 China Journal of Traditional Chinese Medicine and Pharmacy
基金 国家自然科学基金项目(No.81373552,No.81973752) 福建省自然科学基金项目(No.2018J01892) 福建省2011中医健康管理协同创新项目(No.JG2017009-协同) 载人航天领域预先研究项目(No.020104)。
关键词 热证 病位 嗅诊 气味图谱 电子鼻 口腔呼气 Heat syndrome Disease location Olfactory diagnosis Odor response pattern Electronic nose Oral exhalation
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