基于血管性痴呆病症特点的动物模型分析

Animal models analysis based on the characteristics of vascular dementia

目的:基于血管性痴呆中西医临床病症特点,分析目前常用血管性痴呆动物模型,探讨现有模型与临床病症的吻合情况。方法:通过整理分析血管性痴呆动物模型的中西医诊断标准、优缺点及其临床症状吻合度,进而提出制作复合性血管性痴呆动物模型的设想。结果:两血管阻断法及改良两血管阻断法和肾虚血瘀型动物模型为较高吻合度动物模型,多以西医发病机制为出发点,中医学证候体现较差。结论:应当利用现有的动物模型与临床病证相结合建立复合动物模型,制定同时体现中西医临床病症特点的动物模型并建立合理的模型评价体系,是血管性痴呆中医药未来研究的重点。

Objective: Based on clinical characteristics of vascular dementia(VD) in Chinese and western medicine, animal models of VD commonly used at present were analyzed, and the coincidence between existing models and clinical symptoms was discussed. Methods: By sorting out and analyzing the diagnostic criteria, advantages and disadvantages of VD animal models and their clinical symptoms, the idea of making compound VD animal models was put forward. Results: 2-VO and the modified 2-VO method and the animal models of kidney deficiency and blood stasis were highly consistent with each other. Conclusion: It is the focus of future research on VD traditional Chinese medicine to establish a compound animal model with the combination of existing animal models and clinical syndromes, to establish an animal model that reflects the clinical characteristics of traditional Chinese and western medicine and to establish a reasonable model evaluation system.