成瘾物质线索反应性及其神经机制的研究进展

Research progress in cue-reactivity of addictive substance and its neural mechanism

成瘾物质的线索反应性是成瘾者暴露于成瘾物质相关线索时在生理、行为、脑功能等方面出现的变化和反应。线索反应性是物质成瘾的特征之一,是诱发渴求、预测复吸的重要因素,但其神经机制尚不明确。该文整理和总结了目前关于成瘾物质线索反应性神经机制的研究进展和基于线索反应性的临床治疗情况,以帮助更好地理解成瘾的发生发展,从而制定高效的临床干预策略。

Cue-reactivity of addictive substance is a kind of evoked physiological,behavioural and neural responses when an individual is exposed to cues previously associated with addictive substance taking.Cue-reactivity is one of the main features of addiction.It can evoke craving and plays an important role in relapse.However,the neuromechanism is still unknown.The review summarizes recent research progress in the neuromechanism of cuereactivity and the condition of clinical therapies based on cue-reactivity,which helps deeply understand the development of addiction and set effective clinical intervention strategy.