血浆中肿瘤M2型丙酮酸激酶检测对结肠癌与结肠息肉鉴别诊断的临床价值

Clinical Value of Plasma Tumor M2 Pyruvate Kinase in Differential Diagnosis of Colon Cancer and Colon Polyps

目的探讨血浆中肿瘤M2型丙酮酸激酶检测(TUM2-PK)对结肠癌与结肠息肉的鉴别诊断意义。方法选取我院2017年3月至2019年6月经病理诊断确诊的50例结肠癌患者和126例结肠息肉患者为研究对象,并选取90例健康者作为健康对照,对比血浆中TUM2-PK数值和癌胚抗原(CEA)的水平。结果结肠癌组的TUM2-PK的含量明显高于结肠息肉组、健康组(P<0.05);结肠癌组的CEA水平均明显高于结肠息肉组、健康组(P<0.05)。TUM2-PK、CEA的敏感度分别为83.3%、72.7%,具有显著差异(P<0.05);TUM2-PK、CEA的特异度分别为94.4%、90.1%,无明显差异(P>0.05)。结论血浆中肿瘤M2型丙酮酸激酶检测在结肠癌患者诊断中具有重要的临床价值,其敏感性明显高于CEA检测的水平,可以有效提高诊断的有效性。

Objective To investigate significance of tumor M2 pyruvate kinase (TUM2-PK) in differential diagnosis of colon cancer and colon polyps.Methods We chose 50 cases of colon cancer patients and 126 cases colon polyps patients with pathological diagnosis from March 2017 to June 2019 as research objects,and 90 cases of healthy subjects.Compared plasma TUM2-PK value and carcinoembryonic antigen (CEA) levels.Results Contents of TuM2-PK in colon cancer group were significantly higher than those in colon polyp group and healthy group (P<0.05);CEA level in colon cancer group was significantly higher than that in colon polyp group and healthy group (P<0.05).Sensitivity of TUM2-PK and CEA was 83.3% and 72.7% respectively (P<0.05),and specificity of TUM2-PK and CEA was 94.4% and 90.1% respectively (P>0.05).Conclusion Detection of tumor M2 pyruvate kinase has important clinical value in diagnosis of colon cancer,with sensitivity significantly higher than CEA detection,which can improve effectiveness of diagnosis.