老年人抗生素相关性腹泻的研究进展

Research Progress of Elderly Antibiotic Associated Diarrhea

抗生素相关性腹泻是由于接受抗生素治疗而引起,排除其他疾病可能,仅与抗生素相关的一系列严重程度不同、以腹泻为主要症状的肠道菌群失调症的总称。老年人因免疫力和胃肠功能逐渐下降、基础疾病较多,更易反复住院而并发感染,不可避免的出现抗生素的大量应用,肠道的正常生态平衡更易破坏,故老年人抗生素相关性腹泻的发生率、病死率也随之增加。临床上多通过详细病史、治疗详况、临床表现及粪便涂片、培养、肠镜检查等明确诊断,一旦确诊,立即停用或调换抗生素,并配合微生态调节剂、粪菌移植及中医药治疗,能及时预防和减少老年人抗生素相关性腹泻的发生。本文就老年人抗生素相关性腹泻目前的研究进展进行综述。

Antibiotic associated diarrhea is caused by antibiotic treatment.Excluding other diseases,it is a series of intestinal flora disorders with main symptoms of different severity and diarrhea.Due to gradual decline of immunity and gastrointestinal function,basic diseases and frequent hospitalization,it is inevitable for the elderly to take large amount of antibiotics,and normal ecological balance of intestine may be destroyed.Therefore,incidence and mortality of antibiotic associated diarrhea of elderly may increase.Clinical diagnosis is made by detailed medical history,treatment details,clinical manifestations,fecal smear,culture,colonoscopy,etc.Once diagnosis is confirmed,antibiotics should be stopped or replaced immediately,and combined with microecological regulator,fecal bacteria transplantation and traditional Chinese medicine treatment,which can prevent and reduce occurrence of antibiotic associated diarrhea of the elderly.The article reviews current research progress of antibiotic associated diarrhea of the elderly.