社区应用二甲双胍预防糖尿病有效性对照研究

Effective Control Study of Metformin in Preventing Diabetes Mellitus in Community

目的探讨社区应用二甲双胍预防糖尿病有效性的对照研究。方法收集2018年4月至2019年4月东莞市南城社区内常住居民3684例血清,根据血糖水平招募糖尿病前期病人受试者共120例,随机分为试验组(60例)和对照组(60例)。对照组予以生活方式干预,试验组在对照组的基础上予以二甲双胍片。比较两组患者监测空腹血糖、餐后2h血糖、糖化血糖蛋白及体重指数。结果治疗后对照组糖尿病发生率为20.56%,试验组糖尿病发生率为8.41%,两组糖尿病发病率差异存在统计学意义(P<0.05)。治疗后试验组FPG、2hPG、HbAlc、体重指数均低于对照组(P<0.05)。结论采取二甲双胍联合生活方式干预对社区糖尿病前期患者,相比单纯生活方式干预临床症状的效果更为显著。

Objective To investigate effect of metformin on prevention of diabetes mellitus in community.Methods Collect 3684 serum samples of residents in Nancheng community of Dongguan city from April 2018 to April 2019,and recruit 120 subjects with pre diabetes according to blood glucose level,divided them into experimental group (60 cases) and control group (60 cases) randomly.Control group was treated with lifestyle intervention,and experimental group with metformin tablets on the basis of control group.Compare fasting blood glucose and fasting blood glucose index between two groups.Results Diabetes incidence in treatment group was 20.56%,and that in experimental group was 8.41%.There was significant difference in diabetes incidence between two groups (P<0.05).After treatment,FPG,2hPG,HbAlc and BMI in experimental group was lower than control group (P<0.05).Conclusion Metformin combined with lifestyle intervention can achieve more significant effect on clinical symptoms of patients with pre diabetes in community than simple lifestyle intervention.