丁苯酞序贯治疗中青年急性脑梗死的疗效及安全性研究

Study on the Efficacy and Safety of Butylphthalide Sequential Treatment of Acute Cerebral Infarction in Young and Middle-aged

目的探究丁苯酞序贯治疗中青年急性脑梗死的治疗效果与安全性。方法便利选取该院2017年5月—2020年4月期间接受诊治的急性脑梗死患者127例,随机分为对照组和观察组,对照组63例,观察组64例。对比两组急性脑梗死患者的治疗效果,患者的神经系统NIHSS评分以及不良反应的发生情况。结果观察组患者治疗有效率(96.88%)显著高于对照组(85.71%),差异有统计学意义(χ^(2)=4.999,P=0.025);两组患者经过治疗后,观察组患者的神经功能评分(4.04±1.02)分显著低于对照组患者的神经功能评分(6.26±1.86)分,差异有统计学意义(t=8.357,P=0.001);观察组患者不良反应发生率(9.38%)与对照组患者不良反应(9.52%),其差异无统计学意义(χ^(2)=0.001,P=0.977)。结论在治疗急性脑梗死中,实施丁苯酞序贯治疗的疗效更加显著,对患者的神经功能有明显改善。

Objective To explore the therapeutic effect and safety of butylphthalide in sequential treatment of acute cerebral infarction in the young and middle-aged.Methods 127 patients with acute cerebral infarction who were diagnosed and treated in the hospital from May 2017 to April 2020 were conveniently selected and randomly divided into control group and observation group,with 63 cases in control group and 64 cases in observation group.The two groups of patients with acute cerebral infarction were compared of the effect of treatment,the patient’s neurological NIHSS score and the occurrence of adverse reactions.Results The effective rate of treatment in the observation group(96.88%)was significantly higher than that in the control group(85.71%),and the difference was statistically significant(χ^(2)=4.999,P=0.025);after the two groups of patients were treated,the observation group had a neurological score(4.04±1.02)points significantly lower than the neurological function score of patients in the control group(6.26±1.86)points,and the difference was statistically significant(t=8.357,P=0.001);the incidence of adverse reactions in the observation group(9.38%)and the adverse reactions in the control group(9.52%),the difference was not statistically significant(χ^(2)=0.001,P=0.977).Conclusion In the treatment of acute cerebral infarction,the effect of sequential butylphthalide therapy is more significant,and the neurological function of patients is significantly improved.