气管镜肺泡灌洗治疗重症支气管肺炎的临床效果观察

Clinical effect observation of bronchoscope alveolar lavage in the treatment of severe bronchopneumonia

目的探讨气管镜肺泡灌洗治疗重症支气管肺炎的临床效果。方法 92例重症支气管肺炎患者作为研究对象,按随机排列法分为参照组和研究组,各46例。参照组予以常规治疗,研究组在参照组基础上加用气管镜肺泡灌洗治疗。观察比较两组患者治疗前后氧合指数(OI)、肺动态顺应性(Cdyn)及C反应蛋白(CRP)、降钙素原(PCT)水平,湿啰音消失时间、退热时间、住院时间。结果治疗后,两组OI、Cdyn均高于治疗前,且研究组高于参照组,差异有统计学意义(P<0.05)。研究组湿啰音消失时间(11.25±2.86)d、退热时间(4.52±1.24)d、住院时间(13.82±3.16)d均短于参照组的(16.53±3.97)、(9.42±2.81)、(20.58±5.47)d,差异有统计学意义(P<0.05)。治疗后,两组血清CRP、PCT水平均较治疗前降低,且研究组降低幅度大于参照组,差异有统计学意义(P<0.05)。结论重症支气管肺炎采用气管镜肺泡灌洗治疗能够有效改善患者的症状及肺通气功能,减轻炎症反应,缩短住院时间,临床效果显著。

Objective To discuss the clinical effect of bronchoscope alveolar lavage in the treatment of severe bronchopneumonia. Methods A total of 92 patients with severe bronchopneumonia were divided into reference group and research group according to random arrangement method, with 46 cases in each group. The reference group was treated with conventional therapy, and the research group was treated with bronchoscope alveolar lavage based on the reference group. The oxygenation index(OI), pulmonary dynamic compliance(Cdyn), C-reactive protein(CRP), procalcitonin(PCT) levels before and after treatment, the disappearance time of moist rales, antipyretic time, and hospitalization time were observed and compared between the two groups. Results After treatment, the OI and Cdyn of the two groups were all higher than those before treatment, and the research group was higher than the reference group. The difference was statistically significant(P<0.05). The disappearance time of moist rales(11.25±2.86) d, antipyretic time(4.52±1.24) d, and hospitalization time(13.82±3.16) d of the research group were all shorter than(16.53±3.97),(9.42±2.81) and(20.58±5.47) d of the reference group, and the difference was statistically significant(P<0.05). After treatment, the serum CRP and PCT of the two groups were all lower than those before treatment, and the research group was lower than the reference group, and the difference was statistically significant(P<0.05). Conclusion Bronchoscope alveolar lavage has significant clinical effect on the treatment of severe bronchopneumonia, which can effectively improve the patient’s symptoms and pulmonary ventilation function, reduce inflammation, and shorten the hospitalization time.