急性脑梗死患者应用阿司匹林与氯吡格雷联合治疗的临床效果及不良反应发生率观察

Observation on the clinical effect and incidence of adverse reactions of aspirin combined with clopidogrel in patients with acute cerebral infarction

目的分析阿司匹林与氯吡格雷联合治疗急性脑梗死患者的临床效果以及不良反应。方法 130例急性脑梗死患者,通过电脑抽签的方式分为对照组和观察组,每组65例。对照组患者采用阿司匹林治疗,观察组患者采用氯吡格雷联合阿司匹林治疗。比较两组患者治疗后临床效果及不良反应发生情况。结果治疗后,对照组患者的治疗总有效率为78.46%,观察组患者的治疗总有效率为93.85%,观察组患者的治疗总有效率高于对照组,差异具有统计学意义(P<0.05)。对照组患者的不良反应发生率为10.77%,观察组患者的不良反应发生率为9.23%,两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论相比于单纯采用阿司匹林治疗,阿司匹林与氯吡格雷联合治疗急性脑梗死患者的效果更为显著,且不会对患者的不良反应发生率产生影响。

Objective To analyze the clinical effect and incidence of adverse reactions of aspirin combined with clopidogrel in patients with acute cerebral infarction. Methods A total of 130 patients with acute cerebral infarction were divided into control group and observation group according to computer lottery method, with 65 cases in each group. The control group was treated with aspirin, and the observation group was treated with aspirin combined with clopidogrel. The clinical effect after treatment and occurrence of adverse reactions were compared between the two groups. Results After treatment, the total effective rate of the control group was 78.46%, which was 93.85% of the observation group. The total effective rate of the observation group was higher than that of the control group, and the difference was statistically significant(P<0.05). The incidence of adverse reactions of the control group was 10.77%, which was 9.23% of the observation group. There was no statistically significant difference in incidence of adverse reactions between the two groups(P>0.05). Conclusion Compared with aspirin alone, the combination of aspirin and clopidogrel is more effective in the treatment of patients with acute cerebral infarction, and will not increase the incidence of adverse reactions in patients.