重复经颅磁刺激联合度洛西汀肠溶片治疗复发性抑郁症的研究

Repetitive Transcranial Magnetic Stimulation Combined with Duloxetine Enteric-coated Tablets in the Treatment of Recurrent Depression

目的复发性抑郁症使用重复经颅刺激联合度洛西汀肠溶片治疗对照研究。方法2018年1月—2019年8月时间段内于该院接受诊治的54例复发性抑郁症患者作为研究对象,通过抓阄+患者入院顺序为参考分为两组,即实验组27例(度洛西汀肠溶片疗法)、对照组27例(高频重复经颅刺激+度洛西汀肠溶片疗法),参照HAMD-17量表观察并比对两组患者治疗前后的抑郁程度,以威斯康星卡片测验对比两组患者治疗前后的认知功能。结果治疗后,实验组抑郁程度评分(8.83±3.97)分低于对照组(11.57±3.95)分,组间差异有统计学意义(t=2.542,P<0.05);认知功能评分中认知转移(79.67±6.65)分、感觉输入(90.76±5.12)分、注意力(93.13±6.21)分、信息提取(90.65±4.36)分、抽象概括(87.10±4.45)分优于对照组的(73.57±5.39)分、(86.47±5.43)分、(85.89±5.99)分、(88.23±4.04)分、(79.63±4.27)分,差异有统计学意义(t=3.703、2.987、4.360、2.116、6.294,P<0.05)。结论复发性抑郁症患者使用高频重复经颅刺激联合度洛西汀肠溶片治疗,可以有效缓解抑郁情况,提高患者的认知功能,有利于患者获取较好的预后质量,为其重返社会提供助力。

Objective A controlled study of repeated transcranial stimulation combined with duloxetine enteric-coated tablets in the treatment of recurrent depression. Methods 54 patients with recurrent depression who were diagnosed and treated in the hospital from January 2018 to August 2019 were the research subjects. They were divided into two groups based on the lottery + the order of admission of patients, namely the experimental group 27 cases(Duloxetine entericcoated tablets therapy), 27 cases in the control group(high-frequency repetitive transcranial stimulation + duloxetine enteric-coated tablets therapy), observed and compared the depression levels of the two groups before and after treatment with reference to the HAMD-17 scale, the Wisconsin Card Test was used to compare the cognitive function of the two groups of patients before and after treatment. Results After treatment, the score of depression in the experimental group(8.83±3.97) points was lower than that of the control group(11.57±3.95)points, and the difference between the groups was statistically significant(t =2.542, P <0.05);cognitive transfer in the cognitive function score(79.67±6.65) points, sensory input(90.76±5.12) points, attention(93.13±6.21) points, information extraction(90.65±4.36) points, abstract summary(87.10±4.45) points were better than the control group(73.57±5.39) points,(86.47±5.43)points,(85.89±5.99) points,(88.23±4.04) points,(79.63±4.27) points, the difference was statistically significant(t=3.703, 2.987, 4.360, 2.116, 6.294, P<0.05). Conclusion The use of high-frequency repetitive transcranial stimulation combined with duloxetine enteric-coated tablets in patients with recurrent depression can effectively alleviate depression, improve patients’ cognitive function, and help patients obtain better prognosis quality, which provides assistance for their back to the society.