儿童腺病毒肺炎肺损伤机制的研究进展

Research progress on lung injury mechanism of adenovirus pneumonia in children

人腺病毒是一种DNA病毒,是我国儿童呼吸道感染的一种常见病原体。腺病毒感染后可触发多种机制,引起肺组织细胞的溶解和坏死,最终导致肺损伤及肺部后遗症,包括急性呼吸窘迫综合征、肺实变等急性期损伤及感染后闭塞性毛细支气管炎、单侧透明肺、支气管扩张、肺间质纤维化等肺部后遗症。现针对腺病毒感染引起儿童肺损伤的发病机制进行综述。

Human adenovirus is a DNA virus and a common pathogen of respiratory tract infection in children of China.Adenovirus can trigger a variety of mechanisms,thereby dissolving and killing lung cells.Consequently,it leads to such acute lung injury as acute respiratory distress and lung consolidation,and such pulmonary sequelae as bronchiolitis obliterates,unilateral transparent lung,bronchiectasis,and interstitial fibrosis.In this article,the mechanism underlying children lung injury caused by adenovirus was reviewed.