血清CA125、HE4水平与子宫内膜癌患者淋巴结转移的相关性

Correlation between serum CA125,HE4 levels and lymph node metastasis in patients with endometrial carcinoma

目的探讨血清糖类抗原125(CA125)、人附睾蛋白4(HE4)水平与子宫内膜癌患者淋巴结转移的相关性。方法选择2018年7月—2020年2月于我院接受治疗的68例子宫内膜癌患者为研究对象,所有入选者均行MRI检查淋巴结转移情况,并接受血清CA125、HE4水平检测,分析血清CA125、HE4水平与子宫内膜癌患者淋巴结转移的相关性。结果经MRI检查结果显示,68例子宫内膜癌患者发生淋巴结转移9例,占13.24%;未发生淋巴结转移59例,占86.76%;子宫内膜癌患者淋巴结转移与年龄、体重指数、子宫内膜厚度、绝经情况无关,差异无统计学意义(P>0.05);子宫内膜癌患者淋巴结转移与血清CA125、HE4水平有关,差异有统计学意义(P<0.05);经Logistic回归分析结果显示,血清CA125、HE4水平升高是导致子宫内膜癌患者发生淋巴结转移的危险因素(OR>1,P<0.05);绘制ROC曲线,结果显示,血清CA125、HE4水平预测子宫内膜癌患者发生淋巴结转移的AUC分别为0.825、0.835,均具有一定预测价值。结论血清CA125、HE4水平与子宫内膜癌患者淋巴结转移情况密切相关,其水平升高是患者发生淋巴结转移的重要影响因素,临床可通过监测患者血清CA125、HE4水平,对患者淋巴结转移的预防及治疗提供可靠依据。

Objective:To investigate the correlation between serum carbohydrate antigen 125(CA125),human epididymal protein 4(HE4)levels and lymph node metastasis in patients with endometrial carcinoma.Methods:Sixty-eight patients with endometrial carcinoma in our hospital from February 2018 to July 2020 were retrospectively analyzed,all patients underwent MRI examination,the condition of lymph node metastasis was measured,their serum CA125 and HE4 levels were detected,and the correlation between serum CA125,HE4 levels and lymph node metastasis in patients with endometrial carcinoma was analyzed.Results:The result of MRI examination showed that,among 68 cases of patients with endometrial carcinoma,lymph node metastasis occurred in 9 cases,accounting for 13.24%;lymph node metastasis didn't occur in 59 cases,accounting for 86.76%;lymph node metastasis in patients with endometrial carcinoma was not associated with age,body mass index,endometrial thickness and menopause,and the difference was not significant statistically(P>0.05);the levels of CA125 and HE4 were correlated with lymph node metastasis in patients with endometrial carcinoma,and the difference was significant statistically(P<0.05);the results of Logistic regression analysis showed that increasing serum CA125 and HE4 levels were risk factors for lymph node metastasis in patients with endometrial carcinoma(OR>1,P<0.05);the ROC curve was drawn,and the results showed that serum CA125 and HE4 levels predicted the AUC of lymph node metastasis in patients with endometrial carcinoma were 0.825 and 0.835 respectively,which had certain predictive value.Conclusion:Serum CA125 and HE4 levels are closely related to lymph node metastasis in patients with endometrial carcinoma,the increase of their levels is an important factor in the occurrence of lymph node metastasis in patients with this disease,serum CA125 and HE4 levels can be monitored clinically to provide a reliable basis for the prevention and treatment of lymph node metastasis in patients with this disease.