基于VOSviewer对成纤维细胞生长因子23相关研究的可视化分析

Visual analysis of fibroblast growth factor 23 related studies based on VosViewer

目的对成纤维细胞生长因子23(FGF23)相关研究热点和趋势进行可视化分析,为国内研究者提供研究思路及方向。方法检索Web of Science核心合集库中2000年1月—2020年5月关于FGF23相关研究文献,使用VOSviewer软件进行年发文趋势、国家、机构、作者、关键词的可视化分析。结果共纳入文献3430篇,年发文量呈逐年增加趋势。美国是文献产出最多的国家,最高产作者为Wolf M,哈佛大学为发文量最多研究机构。FGF23领域高频关键词包括慢性肾脏病、磷酸盐、甲状旁腺素、维生素D、Klotho等,形成5大聚类,心肌纤维化、尿毒症性心肌病及临床治疗是未来研究方向。结论目前FGF23相关研究集中于病理机制及临床观察研究,缺乏有效的靶向药物治疗研究,未来可进一步加强靶向药物研发。

Objective To analyze the research hotspot and trends of fibroblast growth factor 23(FGF23)by visual analysis,and to provide research ideas and directions for domestic researchers.Methods Research literatures related to FGF23 were retrieved from the core collection database of Web of Science from January 2000 to May 2020,and VOSviewer software was used to conduct visual analysis of annual publication trends,countries,institutions,authors and keywords.Results A total of 3430 literatures were included,and the volume of publication showed an increasing trend year by year.The largest literature output country was United States,the most prolific author was Wolf M,and Harvard University was the research institution with the largest publication volume.The high-frequency keywords in FGF23 field included chronic kidney disease,phosphate,parathyroid hormone,vitamin D,Klotho,etc.,forming five clusters.Myocardial fibrosis,uremia cardiomyopathy and its clinical treatment were the future research directions.Conclusion At present,researches related to FGF23 focus on the pathological mechanism and clinical observation studies,and there is a lack of effective targeted drug therapy studies.In the future,targeted drug research and development can be further strengthened.