虫草补肾胶囊治疗气阴两虚型糖尿病肾病患者的效果

Effect of Chongcao Bushen Capsules in the treatment of diabetic nephropathy patients with deficiency of both qi and yin type

目的观察虫草补肾胶囊对气阴两虚型糖尿病肾病患者血清转化生长因子β1(TGF-β1)、结缔组织生长因子(CTGF)、单核细胞趋化蛋白1(MCP-1)、肿瘤坏死因子α(TNF-α)、活性氧(ROS)、超氧化物歧化酶(SOD)水平的影响。方法选取石家庄市中医院内分泌科和肾内科2018年3月—2019年6月收治的糖尿病肾病患者60例,采用随机数字表法将其分为治疗组和对照组,各30例。治疗组给予虫草补肾胶囊+常规治疗,对照组给予虫草补肾胶囊模拟剂+常规治疗,疗程为6周。比较两组血清TGF-β1、CTGF、MCP-1、TNF-α、ROS、SOD水平。结果治疗后,两组TGF-β1、CTGF、MCP-1、TNF-α水平均低于治疗前,且治疗组低于对照组,差异有统计学意义(P<0.05)。治疗后,两组ROS水平低于治疗前,SOD水平高于治疗前,且治疗组ROS水平低于对照组,SOD水平高于对照组,差异有统计学意义(P<0.05)。结论虫草补肾胶囊可以减缓糖尿病肾病患者肾纤维化的进程,可能与调节细胞因子和抑制炎症反应、氧化应激有关,是一种治疗糖尿病肾病、控制其病情进展的有效药物。

Objective To observe the effect of Chongcao Bushen Capsules on serum levels of transforming growth factor-β1(TGF-β1),connective tissue growth factor(CTGF),monocyte chemoattractant protein-1(MCP-1),tumor necrosis factor-α(TNF-α),reactive oxygen species(ROS)and superoxide dismutase(SOD)in patients with diabetic nephropathy of qi and yin deficiency type.Methods Sixty patients with diabetic nephropathy in Department of Endocrinology and Nephrology of Shijiazhuang Hospital of Traditional Chinese Medicine from March 2018 to June 2019 were selected and divided into treatment group and control group according to random number table method,with 30 cases in each group.Treatment group was given Chongcao Bushen Capsules and conventional treatment,and control group was given Chongcao Bushen Capsules Simulant and conventional treatment.The course of treatment was 6 weeks.The serum levels of TGF-β1,CTGF,MCP-1,TNF-α,ROS and SOD were compared between two groups.Results After treatment,the levels of TGF-β1,CTGF,MCP-1 and TNF-αin two groups were lower than those before treatment,and those in treatment group were lower than those in control group,the differences were statistically significant(P<0.05).After treatment,the level of ROS in two groups was lower than that before treatment,and the level of SOD was higher than that before treatment,and the level of ROS in treatment group was lower than that in control group,and the level of SOD was higher than that in control group,the differences were statistically significant(P<0.05).Conclusion Chongcao Bushen Capsules can slow down the process of renal fibrosis in diabetic nephropathy patients,which may be related to regulating cytokines,inhibiting inflammatory response and oxidative stress.Chongcao Bushen Capsules is an effective drug for the treatment of diabetic nephropathy and the control of its progress.