腹腔镜输卵管切除术对异位妊娠患者的血清β-HCG、血常规及C反应蛋白水平和生育结局的影响

Effect of laparoscopic salpingectomy on serumβ-HCG,blood routine and C-reactive protein levels and reproductive outcome in patients with ectopic pregnancy

目的研究腹腔镜输卵管切除术对异位妊娠患者的血清β-人绒毛膜促性腺激素(β-HCG)、血常规及C反应蛋白水平及生育结局的影响。方法选取2017年9月—2020年9月解放军联勤保障部队第九〇一医院接诊的110例异位妊娠患者为研究对象。依据随机数字表法将其分为研究组和对照组,每组55例。研究组采用腹腔镜输卵管切除术治疗,对照组采用异位妊娠药物杀胚保守治疗。比较两组血清β-HCG水平,血清β-HCG下降幅度,血清β-HCG恢复正常水平所用时间,住院时间,生育结局(排卵率、妊娠率、异位妊娠率),血常规及C反应蛋白。结果治疗前,两组血清β-HCG水平比较,差异无统计学意义(P>0.05);治疗72 h后,两组血清β-HCG水平低于治疗前,且研究组低于对照组,差异均有高度统计学意义(均P<0.01)。研究组治疗72 h后血清β-HCG下降幅度大于对照组,血清β-HCG恢复正常水平时间短于对照组;研究组住院时间短于对照组,差异均有高度统计学意义(均P<0.01)。治疗后两组排卵率及异位妊娠率比较,差异无统计学意义(P>0.05)。研究组妊娠率高于对照组,差异有统计学意义(P<0.05)。两组血常规及C反应蛋白比较,差异无统计学意义(P>0.05)。结论腹腔镜输卵管切除术治疗异位妊娠效果显著,有利于血清β-HCG水平的恢复,提高患者术后妊娠率,缩短住院时间,术后无感染,恢复良好,安全性高,具有临床应用价值,值得推广。

Objective To study the effect of laparoscopic salpingectomy on serumβ-human chorionic gonadotropin(β-HCG),blood routine and C-reactive protein levels and reproductive outcome in patients with ectopic pregnancy.Methods A total of 110 cases of ectopic pregnancy admitted by the 901 Hospital of the Joint Logistic Support Force of the People’s Liberation Army from September 2017 to September 2020 were selected as study objects.According to the random number table method,they were divided into study group and control group,with 55 cases in each group.Study group was treated with laparoscopic salpingectomy,and control group was treated with ectopic pregnancy drug embryo killing conservative treatment.The serumβ-HCG level,the decreasing extent of serumβ-HCG level,the time taken for serumβ-HCG level to return to normal level,hospital stay,reproductive outcome(ovulation rate,pregnancy rate,ectopic pregnancy rate),blood routine and C-reactive protein were compared between two groups.Results Before treatment,there was no significant difference in serumβ-HCG level between two groups(P>0.05).After 72 h of treatment,serumβ-HCG level in both groups were lower than those before treatment,and study group was lower than control group,and the differences were all highly statistically significant(all P<0.01).After 72 h of treatment,the decreasing extent of serumβ-HCG level in study group was greater than that in control group,and the time taken for serumβ-HCG level to return to normal level was shorter than that in control group;hospital stay of study group was shorter than that of control group,and the differences were highly statistically significant(all P<0.01).There were no significant differences in ovulation rate and ectopic pregnancy rate between two groups after treatment(P>0.05).The pregnancy rate in study group was higher than that in control group,and the difference was statistically significant(P<0.05).There were no significant differences in blood routine and C-reactive protein between two groups(P>0.05).Conclusion Laparoscopic salpingectomy in the treatment of ectopic pregnancy has significant curative effect,which is conducive to the recovery of serumβ-HCG level,improving postoperative pregnancy rate of patients,shortening the hospital stay,no infection after operation,good recovery and high safety.It has clinical application value and is worthy of promotion.