拉氧头孢钠合成工艺的改进

Synthesis of Latamoxef Disodium

以7β-氨基-7α-甲氧基-3-(1-甲基-5-四唑基)硫甲基-1-氧杂去硫杂-3-头孢烯-4-羧基二苯甲酯,经缩合反应,再用四氯化钛脱羧基保护,最终用异辛酸钠成盐,溶剂法得拉氧头孢钠,总收率约81.4%。

Latamoxef disodium was prepared from 7β-amino-7α-methoxy-3-(1-methyl-5-tetrazolyl)sulfanylmethyl-1-oxo-3-cephem-4-carboxyldiphenylmethylest-er,after condensation reaction,hydrolysis with titanium tetrachloride,and final-y salt with sodium isooctanoate,and solvent method to obtain latamoxet disodi-um,with an overall yield of about 81.4%.