摘要
胰腺癌是恶性程度较高的消化系统肿瘤之一,由于其隐匿性强、预后差、复发率高以及治疗过程中不断产生的耐药性,所导致的疾病负担日益加重,同时也促进了基础及临床研究的不断进步。近年来,随着精准医学理念的提出,基于二代测序开展的靶向治疗、免疫治疗等技术为胰腺癌的诊断和治疗提供了新机遇。本文就目前胰腺癌在精准医学治疗领域中的研究热点进行综述,以期能为胰腺癌的基础与临床研究提供一定的参考价值。
Pancreatic cancer is one of the most malignant tumors in the human digestive system.Due to its strong concealment,poor prognosis,high recurrence rate and drug resistance,the disease burden caused by pancreatic cancer is gradually increasing.This increasing disease burden has also led to advances both in basic medical and clinical research.In recent years,targeted therapy and immunotherapy based on nextgeneration sequencing provide new opportunities for the diagnosis and treatment of pancreatic cancer.This article summarized the current research hotspots in the field of precision medicine in the treatment of pancreatic cancer,hoping to provide some reference values for the basic medical and clinical research in pancreatic cancer.
作者
雷洋洋(综述)
王小林(审校)
LEI Yang-yang;WANG Xiao-lin(Shanghai Institute of Medical Imaging,Shanghai 200032,China;Department of Interventional Radiology,Zhongshan Hospital,Fudan University,Shanghai 200032,China)
出处
《复旦学报（医学版）》
CAS
CSCD
北大核心
2021年第2期255-260,共6页
Fudan University Journal of Medical Sciences
基金
上海市慈善基金会荣昶专项基金(Q2015-024)。
关键词
胰腺癌
二代测序
免疫治疗
精准医学
pancreatic cancer
next-generation sequencing
immunotherapy
precision medicine
