血清PCT、CRP及血常规对早期败血症的诊断价值

Significance of serum PCT,CRP and blood routine examination in improving the accuracy of early diagnosis of sepsis

目的观察早期败血症诊断中应用血清降钙素原(PCT)、C反应蛋白(CRP)以及血常规的价值,为败血症的临床诊断提供参考。方法回顾性分析2018年12月—2019年12月本院收治100例患儿临床资料。将经临床相关检查证实为败血症的50例患儿作为研究组,同期在本院医治非败血症50例患儿作为参照组。检测两组研究对象血清PCT、CRP以及血常规水平,对比各项指标单独检测和联合检测的敏感度、特异度和准确性。结果研究组患儿白细胞计数(WBC)、血清PCT、CRP、中性粒细胞计数相较参照组均明显更高,两组差异有统计学差异(P<0.05)。单一指标诊断中,血清PCT的敏感度和特异度最高;而血清PCT、CRP、WBC、中性粒细胞计数联合检验的敏感度、特异度以及准确性均高于单独指标检验,差异具有统计学意义(P<0.05)。结论败血症患儿血常规、血清PCT、CRP水平存在明显异常改变,联合上述指标进行检验有利于提高检查的准确性,对败血症早期诊断具有重要指导价值,值得推广。

Objective To observe the value of serum procalcitonin(PCT),C-reactive protein(CRP)and blood routine examination in the early diagnosis of sepsis,so as to provide reference for the clinical diagnosis of sepsis.Methods The clinical data of 100 children those admitted to our hospital from December 2018 to December 2019 were retrospectively analyzed.50 children with septicemia that confirmed by clinical examination were selected as the study group,and 50 cases of patients without septicemia those treated in our hospital at the same time were selected as the reference group.The serum PCT,CRP and blood routine levels of the two groups were detected,and the sensitivity,specificity and accuracy of each index were compared.Results The white blood cell count(WBC),serum PCT,CRP,and neutrophil counts of the study group were significantly higher than those of the reference group,and there was a statistical difference between the two groups(P<0.05).In the single index diagnosis,the sensitivity and specificity of serum PCT are the highest.The sensitivity,specificity and accuracy of the combined test of serum PCT,CRP,WBC and neutrophil count are higher than those of the single index test,and the differences were statistically significant(P<0.05).Conclusions The blood routine test,serum PCT,CRP levels in children with sepsis have obvious abnormal changes,the combined detection of the above indicators is conducive to improve the accuracy of the examination,has important guiding value for the early diagnosis of sepsis,and is worthy of promotion.