银杏叶提取物制剂序贯疗法对老年血管性痴呆患者记忆、认知及血流状态的影响

Sequential Therapy of Ginkgo Biloba Extract Preparation to Improve Memory,Cognition and Blood Flow Status in Elderly Patients with Cerebrovascular Dementia

目的探讨银杏叶提取物制剂序贯疗法对老年血管性痴呆患者记忆、认知及血流状态的影响。方法选取2017年9月至2018年12月沈阳医学院附属中心医院收治的86例老年脑血管性痴呆患者作为研究对象,按治疗方法不同分为对照组(40例)与观察组(46例)。两组给予常规治疗,其中包括改善微循环、抗血小板聚集等,对照组在常规治疗基础上采用舒血宁注射液治疗,观察组在常规治疗基础上给予舒血宁注射液,7~10 d后改用银杏叶片,累计治疗21 d。比较两组患者记忆、认知及血流状态。结果治疗后,观察组韦氏智力测验记忆测验第四版(WMS-Ⅳ)中文版(成人版)中的词语配对、视觉再现、逻辑记忆、空间叠加、图形重置评分及总分显著高于对照组,差异有统计学意义(P<0.05);治疗后,观察组简易认知状态评价量表(MMSE)显著高于对照组,差异有统计学意义(P<0.05);治疗后,观察组左大脑前动脉(L-ACA)、右大脑前动脉(R-ACA)、左大脑中动脉(L-MCA)、右大脑中动脉(R-MCA)及基底动脉(BA)血流速度显著快于对照组,差异有统计学意义(P<0.05)。结论银杏叶提取物制剂序贯疗法治疗老年脑血管性痴呆临床效果较好,可有效改善老年患者的记忆、认知及血流状态。

Objective To investigate the effect of sequential therapy of ginkgo biloba extract preparation on memory,cognition and blood flow status in elderly patients with cerebrovascular dementia.Methods A total of 86 elderly patients with cerebrovascular dementia admitted in Central Hospital Affiliated to Shenyang Medical College from September 2017 to December 2018 were selected as the research objects and were divided into a control group(40 cases)and a research group(46 cases),according to different treatment.Both groups were given routine treatment,including improving microcirculation,anti-platelet aggregation,etc.The control group(n=40)was given Shuxuening Injection on the basis of conventional treatment for 21 days.After 7 d-10 d,the ginkgo leaves were used,and the cumulative treatment was 21 d.The memory,cognition and blood flow status of the 2 groups were compared.Results After treatment,the word pairing,visual reproduction,logical memory,spatial overlay,graphic resetting and total score in the Chinese version(adult version)of the Wechsler Memory Scale 4 th edition(WMS-Ⅳ)were significant higher than the control group,the difference was statistically significant(P<0.05);after treatment,the simple cognitive state assessment scale(MMSE)of the observation group was significantly higher than the control group,the difference was statistically significant(P<0.05);after treatment,left anterior cerebral artery(L-ACA)of the observation group,right anterior cerebral artery(R-ACA),left middle cerebral artery(L-MCA),right middle cerebral artery(R-MCA)and basilar artery(BA)blood flow speed were significantly faster than the control group,and the difference was statistically significant(P<0.05).Conclusion The sequential therapy of ginkgo biloba extract preparation for the treatment of elderly cerebrovascular dementia has a good clinical effect,and it has a significant effect on the memory,cognition and blood flow state of elderly patients.