利福平与左氧氟沙星联合治疗复治涂阳肺结核患者的临床效果

Clinical Effect of Rifampicin Combined with Levofloxacin in the Treatment of Patients with Smear-positive Pulmonary Tuberculosis

目的探讨含利福平与左氧氟沙星的抗结核方案用于复治涂阳肺结核中的临床效果。方法选取2017年4月至2019年5月锦州市传染病医院收治的66例复治涂阳肺结核患者作为研究对象,按随机数字表法将其分为对照组与观察组,各33例。对照组行含利福平的抗结核方案,观察组行含利福平与左氧氟沙星的抗结核方案,对两组治疗结果进行比较。结果观察组空洞闭合时间、痰菌消除时间较对照组短(P<0.05);观察组治疗有效率为90.91%,较对照组69.70%高(P<0.05);观察组治疗后30 min、1 h、2 h的利福平血药浓度与对照组比较差异无统计学意义(P>0.05);观察组不良反应发生率为15.15%,与对照组12.12%比较,差异无统计学意义(P>0.05)。结论含利福平与左氧氟沙星的抗结核方案用于复治涂阳肺结核中效果理想,可缩短空洞闭合及痰菌消除时间,提高临床疗效,促进患者快速康复,且不会对利福平血药浓度造成影响,不良反应较少。

Objective To explore the clinical effect of anti-tuberculosis prescription containing rifampicin and levofloxacin in retreatment of smear-positive pulmonary tuberculosis.Methods A sample of 66 retreated smear-positive pulmonary tuberculosis patients admitted to Jinzhou Infectious Disease Hospital of Liaoning Province from April 2017 to May 2019 were selected as the research objects and were divided into an observation group(n=33)and a control group(n=33)according to the number random table method.The control group received an anti-tuberculosis program containing rifampicin,and the observation group received an anti-tuberculosis program containing rifampin and levofloxacin.The treatment results of the 2 groups were compared.Results The cavity closure time and the elimination time of sputum bacteria in the observation group were shorter than those in the control group(P<0.05);the total effective rate in the observation group was 90.91%,which was higher than 69.70% in the control group(P<0.05);there was no significant difference in the blood concentration of rifampicin in the observation group 30 min,1 h,2 h after treatment compared with the control group(P>0.05);the adverse reaction rate in the observation group was 15.15%.There was no significant difference compared with 12.12% in the control group(P>0.05).Conclusion The anti-tuberculosis prescription containing rifampicin and levofloxacin is effective in retreatment of smear-positive pulmonary tuberculosis.It can shorten cavity closure and sputum elimination time,improve clinical efficacy,promote rapid recovery of the disease.It will not affect the blood concentration of rifampicin cause impact,with less adverse reactions.