摘要
近年来,G蛋白偶联雌激素受体(G protein-coupled estrogen receptor,GPER)受到了广泛关注,作为一种雌激素膜受体,GPER在不同组织中都有重要作用。在脑组织中,GPER通过调控多条信号通路,起到了保护神经、增强学习记忆能力、调控情绪等作用。因此,该文主要就GPER在脑组织中调控的信号通路及其作用进行综述,进一步理解GPER对脑组织结构和功能的影响。
In recent years, the G protein-coupled estrogen receptor(GPER) has received worldwide attention. GPER plays an important role in different tissues as an estrogen membrane receptor. In the brain, GPER mediates neuroprotection, enhances learning and memory ability, and regulates emotions by activating multiple signal pathways. Therefore, this paper reviewed the main signaling pathways and functions regulated by GPER in the brain tissue, in order to further understand the influence of GPER on the structure and function of brain.
作者
冯钰
卞学鹏
田旭
商庆慧
娄淑杰
FEN G Yu;BIAN Xue-Peng;TIAN X u;SHANG Q ing-H ui;LOU Shu-Jie(School of Kinesiology,Shanghai University of Sport,Shanghai 200438,China)
出处
《生命科学》
CSCD
北大核心
2021年第1期53-60,共8页
Chinese Bulletin of Life Sciences
基金
上海市人类运动能力开发与保障重点实验室(上海体育学院)(11DZ2261100)
国家自然科学基金项目(31971098)。