摘要
Chirality is a fascinating and essential feature of life and highly associated with many significant pharmaceutical,chemical,and biological processes.The construction of chiral recognition platform is a hot research topic and challenging assignment.Herein,we report an electrochemical method by diffe rential pulse voltammetry(DPV) for the enantioselective recognition of chiral drug propranolol(R/SPPL) through a nanochannel platform based on the N-acetyl-L-cysteine functionalized pillar[5]arenes derivative NALC-P5 and the porous polycarbonate membrane.The chiral discrimination depends on the diffe rence in the supramolecular host-guest interaction between the chiral NALC-P5 and the R/S-PPL.The transmission rate of the R/S-PPL can be regulated in the nanochannel and we can achieve the selective transport of the chiral drugs.This simple electrochemical technique has potential applications as a general platform for the recognition of chiral molecules.
基金
financially supported by the National Key Research and Development Program of China(No.2018YFD0200102)
the National Natural Science Foundation of China(Nos.21772055,21572076,21807083,21911530178)
the Program for Innovative Teams of Outstanding Young and Middleaged Researchers in the Higher Education Institutions of Hubei Province(No.T201702)
the 111 Project(No.B17019E)。
