摘要
The asymmetric synthesis of 16,17,20-epi-deserpidine and a derivative of(-)-deserpidine has been achieved.Key feature s in the assembly of the pentacyclic framework include a visible-light photocatalytic intra-/inter-/intramolecular radical cascade reaction to construct the tetracyclic ABCD ring system in one-pot and an intramolecularaldol reaction to forge the cyclohexane E ring.
基金
the financial surpport from the National Natural Science Foundation of China(Nos.21702140 and21732005)
National Science and Technology Major Projects for“Major New Drugs Innovation and Development”(No.2018ZX09101003-005-004)。
