补阳还五汤结合家庭模式的延续性护理对急性脑梗死患者颅内血流及β2-MG、SOD水平的影响

Effect of Buyang Huanwu Decoction combined with family-based continuous nursing on intracranial blood flow and levels of β2-MG and SOD in patients with acute cerebral infarction

目的探讨补阳还五汤结合家庭模式的延续性护理对急性脑梗死患者颅内血流及β_(2)-MG、SOD水平的影响。方法选取急性脑梗死患者80例,随机分为对照组和观察组。对照组给予拜阿司匹林及辛伐他汀,观察组联合补阳还五汤治疗,7 d为1个治疗周期,连续服用3个周期;同时2组均给予出院后的家庭模式的延续性护理,连续干预3个月。评估患者神经功能和生活能力;比较脑脊液中β_(2)-MG、β-AP、生化指标及颅内血流动力学指标。结果干预后2组NHISS评分及血液样本中MDA和ET-1、脑脊液中β_(2)-MG、β-AP水平低于干预前,观察组低于对照组(P<0.05);2组Barthel指数、MCA、ACA、PCA及血液样本中NO、SOD水平高于干预前,观察组高于对照组(P<0.05)。结论补阳还五汤结合家庭模式的延续性护理对急性脑梗死患者治疗效果显著,可有效降低患者脑脊液中β_(2)-MG、β-AP水平,增强机体清除氧自由基的能力,提高患者生活自理能力,且疗效优于常规治疗。

Objective To explore effect of Buyang Huanwu Decoction combined with family-based continuous nursing on intracranial blood flow and levels ofβ_(2)-MG and SOD in patients with acute cerebral infarction.Methods 80 patients with acute cerebral infarction were randomly divided into control group and observation group.The control group was treated with aspirin and simvastatin,while the observation group was treated with Buyang Huanwu Decoction on the basis of the control group.Seven days was one treatment cycle,and the drugs were taken continuously for three cycles.At the same time,both groups were given continuous family-based care after discharge,and the consecutive intervention lasted for 3 months.The neurological function and living ability of the patients were evaluated,and theβ_(2)-MG,β-AP,biochemical indexes and intracranial blood flow indexes in cerebrospinal fluid(CSF)were compared.Results After intervention,the NHISS score,MDA and ET-1 in blood samples,β_(2)-MG andβ-AP in cerebrospinal fluid of the two groups were lower,and the observation group was significantly lower than those of the control group(P<0.05).The Barthel index,MCA,ACA,PCA,NO and SOD in blood samples of the two groups were higher than those before intervention,and the observation group was significantly higher than those of the control group(P<0.05).Conclusion Buyang Huanwu Decoction combined with family-mode continuous nursing has a significant effect on patients with acute cerebral infarction,which can effectively reduce the levels ofβ_(2)-MG andβ-AP in cerebrospinal fluid,enhance the body ability of scavenging oxygen free radicals,and improve patients’self-care ability,with a significantly better effect than conventional treatment.