静脉吸毒途径HIV感染者发生睡眠障碍的全国多中心调查

A multicenter study on the sleep disorders in people living with HIV through intravenous drug abuse

目的调查静脉吸毒途径艾滋病病毒(HIV)感染者睡眠障碍的发病率及风险因素。方法在全国20个艾滋病治疗机构的HIV感染者中进行横断面调查,收集HIV感染者社会人口学特征及HIV相关临床数据,采用匹兹堡睡眠质量指数问卷及医院焦虑与抑郁自评量表评估感染者睡眠障碍、焦虑障碍和抑郁障碍的患病率,利用Logistic回归模型寻找静脉吸毒途径HIV感染者发生睡眠障碍的相关因素。结果共收集4100例HIV感染者的相关资料,其中255名通过静脉吸毒途径感染,静脉吸毒途径HIV感染者中有55.7%(142例)发生睡眠障碍,高于其他途径感染HIV人群(43.8%)。静脉吸毒途径HIV感染者发生睡眠障碍的风险因素包括抑郁水平[调整比值比(aOR)=2.170,95%可信区间(CI):1.179~3.997,P=0.013]和焦虑水平(aOR=3.279,95%CI:1.647~6.531,P=0.001)。结论静脉吸毒途径HIV感染者常发生睡眠障碍,主要与焦虑障碍、抑郁障碍等精神障碍有关,应受到足够重视。

Objective To investigate the prevalence and risk factors of sleep disorders in people living with HIV(PLWH)through intravenous drug use.Methads This was a cross-sectional survey conducted among PLWHs at 20 AIDS clinics.The socio-demographic characteristics of PLWHs and clinical data related to HIV were collected.The Pittsburgh Sleep Quality Index,Hospital Anxiety and Depression Scale were used to assess sleep disorders,anxiety disorders and depressive disorders respectively.Finally,we used logistic regression to investigate the risk factors for sleep disorders in PLWHs through intravenous drug abuse.Results Of the 4100 PLWHs,255 were infected through intravenous drug use,and 55.7%of PLWHs through intravenous drug use had sleep disorders,which was higher than that of people infected with HIV through other routes(43.8%).The risk factors for sleep disorders in PLWHs through intravenous drug use included depressive disorders(adjusted odds ratio[aOR]=2.170;95%confidence interval[CI],1.179-3.997;P=0.013)and anxiety disorders(aOR=3.279;95%CI,1.647-6.531;P=0.001).Conclusions PLWHs through intravenous drug use often suffer from sleep disorders,which are mainly related to anxiety disorders and depression disorders.