摘要
Innate lymphoid cells (ILCs) are immune cells newly defined inrecent decades and are recognized as the innate counterpart of theT helper cells, including IFNc-producing group 1 ILCs (ILC1s), IL-5and IL-13-producing group 2 ILCs (ILC2s), and IL-22-producinggroup 3 ILCs (ILC3s). Although with a tiny population, ILCs arenot only required for the host to maintain the tissue homeostasisand defense against pathogen invasion but also actively involvedin various inflammatory and allergic diseases [1]. The immune systemis shaped critically in early life, especially when born preterm.Although the development of the immune system in preterm childrenhas been extensively discussed [2], it is still unknownwhether the development of ILCs is influenced by preterm birth.
天然淋巴样细胞(ILCS)是近年来被广泛关注的一类新的免疫细胞,在多种感染性疾病和自身免疫疾病中发挥重要作用.早产儿与足月儿的免疫系统发育具有明显差异,其中天然淋巴样细胞的发育及其与新生期疾病的相关性仍不清楚.本研究发现,不同孕周的早产儿外周血中天然淋巴样细胞比例和细胞因子水平均低于足月儿,体外实验证明早产儿天然淋巴样细胞前体细胞在体外分化能力低于足月儿,同时ILC1、ILC3与1月龄内患呼吸道感染性疾病负相关, ILC2与12月龄内患湿疹正相关.该研究揭示了天然淋巴样细胞在早产儿的发育缺陷,同时为新生期呼吸道感染性疾病和湿疹提供了新的靶点.
作者
Wenyan Wang
Yan Xing
Yanmei Chang
Ying Wang
Yanxia You
Zekun Chen
Defu Ma
Xiaomei Tong
Xiaohuan Guo
王文彦;邢燕;常艳美;王颖;尤艳霞;陈泽琨;马德福;童笑梅;郭晓欢(Institute for Immunology,Tsinghua University,Beijing 100084,China;Department of Basic Medical Sciences,School of Medicine,Tsinghua University,Beijing 100084,China;Beijing Key Lab for Immunological Research on Chronic Diseases,Tsinghua University,Beijing 100084,China;Tsinghua-Peking Center for Life Sciences,Tsinghua University,Beijing 100084,China;Department of Pediatrics,Peking University Third Hospital,Beijing 100191,China;School of Public Health,Peking University Health Science Center,Beijing 100191,China)
基金
This work was supported by the National Natural Science Foundation of China(31821003,91642106,31570923,and 81901603)
the Beijing Natural Science Foundation(S160004 and S170003)
the China Postdoctoral Science Foundation
supported by the Tsinghua-Peking Center for Life Sciences
the Institute for Immunology
the School of Medicine at Tsinghua University。
