纳米金用于肿瘤免疫治疗的研究进展

Advances in Application of Gold Nanoparticles for Cancer Immunotherapy

肿瘤免疫疗法作为一种高效高安全性的抗肿瘤策略,主要通过激活人体免疫系统发挥抗肿瘤效应。多种纳米材料在肿瘤免疫治疗研究中被用于免疫佐剂和疫苗的肿瘤靶向递送。该文主要综述了纳米金作为免疫药物和药物载体在抗肿瘤研究中的应用。纳米金不仅能通过自身的独特优势发挥免疫调节作用,还能够特异性地在体内将免疫制剂运送至效应部位,降低药物的不良反应,提升了免疫药物的作用效果,保障了免疫疗法的安全实施,为肿瘤治疗提供了新思路和新策略。

As an anticancer strategy with high efficacy and security,tumor immunotherapy aims to activate the immune system for the recognizing and killing cancer cells.To acquire efficient im-mune activation,various nanomaterials have been developed for tumor-targeted delivery of immunologic adjuvant and vaccine.In this article,the application of gold nanoparticles as immune agents or drug carriers for anticancer treatment are summarized.Gold nanoparticles not only can play a role of immune regulator,but also can induce a targeted delivery of immune drugs in vivo with a high-efficiency and safe manner.