大剂量厄贝沙坦对冠心病患者颈动脉粥样硬化程度及血清炎性因子水平的影响

Effects of high-dose irbesartan on the degree of carotid atherosclerosis and serum inflammatory factors in patients with coronary heart disease

目的观察大剂量厄贝沙坦对冠心病患者颈动脉粥样硬化程度及血清炎性因子水平的影响。方法选择2017年7月-2019年1月东北输变电设备集团中心医院收治的冠心病患者114例作为研究对象,根据随机分组原则分为观察组(57例)与对照组(57例)。观察组在常规治疗的基础上给予大剂量厄贝沙坦治疗,对照组在常规治疗的基础上给予小剂量厄贝沙坦治疗,比较2组颈动脉粥样硬化程度及血清炎性因子水平。结果治疗后,2组颈动脉斑块厚度、斑块面积及斑块数量均小于治疗前,血清C反应蛋白(CRP)、肿瘤坏死因子α(TNF-α)及白细胞介素-6(IL-6)水平均低于治疗前,且观察组小于/低于对照组,差异均有统计学意义(P<0.01)。结论大剂量厄贝沙坦可有效降低冠心病患者颈动脉粥样硬化程度及血清炎性因子水平,值得临床推广应用。

Objective To observe the effect of high-dose irbesartan on the degree of carotid atherosclerosis and serum inflammatory factor levels in patients with coronary heart disease.Methods A total of 114 patients with coronary heart disease admitted to the Northeast Power Transmission Equipment Group Central Hospital from July 2017 to January 2019 were selected as the research objects.According to the principle of randomization,they were divided into observation group(57 cases)and control group(57 cases).The observation group was given high-dose irbesartan on the basis of conventional treatment,and the control group was given low-dose irbesartan on the basis of conventional treatment.The degree of carotid atherosclerosis and serum inflammatory factor levels were compared between the two groups.Results After treatment,the carotid artery plaque thickness,plaque area,and number of plaques in 2 groups were less than before treatment.Serum C-reactive protein(CRP),tumor necrosis factor-α(TNF-α)and interleukin-6(IL-6)level were lower than before treatment,and the observation group was lower than the control group,the difference were statistically significant(P<0.01).Conclusion High-dose irbesartan can effectively reduce the degree of carotid atherosclerosis and serum inflammatory factor levels in patients with coronary heart disease,and it is worthy of clinical application.