Plasma free fatty acid is associated with ischemic cardiomyopathy and cardiac dysfunction severity in systolic heart failure patients with diabetes

Heart failure(HF)is a worldwide problem due to the substantial morbidity and mortality of patients with cardiovascular diseases.Recently,the PARADIGM-HF trial(the Prospective comparison of angiotensin receptor-neprilysin inhibitor[ARNI]with angiotensin-converting enzyme inhibitor[ACEI]to Determine Impact on Global Mortality and morbidity in Heart Failure trial)showed that ischemic heart disease is the most common etiology of HF,which accounts for 60%of HF with reduced ejection fraction(HFrEF).