Application of single-cell sequencing in autoimmune diseases

To the Editor:The Human Genome Project decodes the mysteries of life,explores the pathogenesis of disease,and provides scientific evidence for the diagnosis and treatment of disease.Traditional sequencing methods predominantly provide genome-wide sequence information and an average of the mix of cell types,which does not take into account the heterogeneity between cells and between subtypes.Advances in genome sequencing technology have allowed the development of single cell sequencing(SCS).