他莫昔芬相关眼部病变的研究进展

Ocular toxicity induced by tamoxifen:an overview

本文回顾总结了近年来他莫昔芬应用于乳腺癌、神经胶质瘤治疗时出现的相关眼部病变的文献,将他莫昔芬导致眼部病变出现的发生率、发病机制、相关眼部病变特征性表现(角膜病变、白内障、视网膜病变、视神经病变以及其他一些少见病变)进行综述,为眼科医师对他莫昔芬眼部病变的识别和眼部病变的监测提供指导。(中华眼科杂志,2021,57:232-236)

By reviewing the recent articles regarding the ocular side effect of tamoxifen when treating breast cancer and glioma,this article summarized the incidence and the potential mechanism of the side effects of tamoxifen,and the specific ocular toxicity including keratopathy,cataract,retinopathy,optic neuropathy.This review would provide guidance for clinical ophthalmologists to early identify and appropriately manage tamoxifen induced ocular diseases.(Chin J Ophthalmol,2021,57:232-236)