中药及复方体内代谢产物鉴别策略研究进展

Identification strategies of Chinese materia medica and complex prescription metabolites in vivo

基于中药及复方体内代谢产物鉴别的未知性和复杂性,从“识别”和“鉴定”两方面概述了近年来中药及复方体内代谢产物鉴别研究的主要方法、策略及技术,对各种方法的适用范围及存在的问题进行了阐述,并提出今后中药及复方体内代谢鉴别研究在分析仪器、分析数据软件、化学成分示踪及对照等方面的发展方向,为相关科研人员在方法选用及策略开发时提供一定的参考。

Based on the unpredictability and complexity of metabolites in vivo of Chinese materia medica(CMM)and complex prescription,this paper summarizes the main methods,strategies and techniques of identification of metabolites in vivo of CMM and complex prescription in recent years from two aspects involving“recognition”and“identification”,illustrates the application scope and existing problems of various methods,and puts forward the developmental direction of metabolites in vivo of CMM and complex prescription in analytical instruments,data analysis software,chemical component tracing and control etc.,thereby providing some ideas and references for relevant scientific researchers in the selection of methods and strategy development.