摘要
荚膜异多糖酸合成调节(Regulator of Capsule Synthesis,Rcs)系统是存在于许多肠杆菌科细菌中非典型的双组分调节系统,由3种核心蛋白(跨膜感应激酶RcsC、跨膜蛋白RcsD和响应调节剂RcsB)及多种辅助蛋白共同构成。Rcs系统能整合环境信号、调节基因表达并改变细菌的生理行为。近年来,对细菌Rcs系统环境应答机制的探索成为一个新的研究热点。本文重点综述Rcs系统上游信号的感知与传导、Rcs系统调节的下游靶基因及其生命现象,以期能增进对细菌Rcs系统的认识,同时为细菌的安全控制、感染预防和治疗新方案的开发提供参考。
The regulator of capsule synthesis(Rcs) system is a non-orthodox two-component regulatory system found in many members of Enterobacteriaceae. This system consists of three core proteins(the transmembrane sensor kinase RcsC, the transmembrane protein RcsD and the response regulator RcsB) and multiple accessory proteins. Rcs system can integrate environmental signals, regulate gene expression and alter the physiological behavior of bacteria. Defining the environmental response mechanism of Rcs system in Enterobacteria has been a major focus in several recent studies. Here, the role of Rcs system in signal perception and conduction, and the target genes regulated by Rcs system and their life phenomena are introduced. This review will highlight the current understanding of the biological role of Rcs system, as well as to provide a theoretical basis for the development of new strategies for bacterial control, prevention and treatment.
作者
孟娇
陈晶瑜
MENG Jiao;CHEN Jingyu(Beijing Laboratory for Food Quality and Safety,College of Food Science and Nutritional Engineering,China Agricultural University,Beijing 100083,China)
出处
《微生物学通报》
CAS
CSCD
北大核心
2021年第1期210-222,共13页
Microbiology China
基金
国家自然科学基金(31671830)
北京市自然科学基金(6202016)。
关键词
Rcs双组分调节系统
信号转导
环境感知
基因调控
Rcs two-component regulatory system
signal transduction
environmental perception
gene regulation
