海南高龄及百岁老人贫血相关检测指标的参考值范围探讨

Reference intervals for anemia-related routine blood test indicators in Hainan oldest-old and Hainan centenarians

目的探讨我国海南高龄及百岁老人贫血相关检测指标的参考值范围。方法数据来源于中国海南高龄及百岁老人队列研究数据库。按照标准化流程,进行问卷调查,体格检查和血液样本分析。对血红蛋白浓度、红细胞计数及血细胞比容3项指标的数据进行统计分析,采用百分位数法统计双侧95%界限,建立医学参考值范围。结果共纳入767名高龄老人(男性312名,占40.7%)与715名百岁老人(男性137名,占19.2%)。血红蛋白的参考值范围在高龄老人男性和女性中分别为89.1~173.5 g/L与94.4~146.0 g/L;在百岁老人男性与女性中分别为68.4~145.6 g/L与81.0~140.0 g/L。结论本研究首次提供了海南高龄及百岁老人贫血相关检测指标的参考值范围,且低于目前成年人的参考标准值范围。

Objective To investigate reference intervals for anemia-related routine blood test indicators in Hainan oldest-old and Hainan centenarians.Methods A cross-sectional data set of China Hainan Centenarians Cohort Study(CHCCS)was used.Household interview,physical examinations,and blood sample analysis were conducted in accordance with standardized procedures.The hemoglobin level,red blood cell count,and hematocrit were analyzed with automatic biochemical analyzer and the reference intervals were determined following CLSI C28-A3 guidelines using a non-parametric method.Results A total of 715 centenarians,including 137 males(19.2%),and 767 long-lived individuals aged≥80 years,including 312 males(40.7%),were surveyed.The reference interval of hemoglobin level was 89.1-173.5 g/L in males and 94.4-146.0 g/L in females,respectively,in long-lived individual group.The reference interval of hemoglobin level was 68.4-145.6 g/L in males and 81.0-140.0 g/L in females,respectively,in centenarian group.Conclusion The reference intervals of hemoglobin level,red blood cell count,and hematocrit were set for the first time for the oldest-old and centenarians in Hainan,which was lower than that currently used in adults.