痰热清注射液对重症肺炎患者的耐药菌感染率改善作用

Effect of Tanreqing Injection on infection rate of drug-resistant bacteria in patients with severe pneumonia

目的分析痰热清注射液辅助治疗重症肺炎的耐药菌感染率改善作用。方法选取2018年1月—2020年9月淮南朝阳医院收治的105例重症肺炎患者作为研究对象,将患者按照治疗方法分为对照组(n=51)和观察组(n=54)。对照组给予对症基础治疗,观察组在对照组的基础上静脉滴注痰热清注射液,10 mL加入到500 mL 5%葡萄糖注射液,1次/d。疗程2周。观察两组患者的临床疗效,比较两组患者的耐药菌检出类型及检出率、耐药病原菌总清除率。结果治疗后,观察组患者总有效率为90.74%,显著高于对照组的76.47%,差异具有统计学意义(P<0.05)。两组患者检出耐药菌类型主要以铜绿假单胞菌、鲍曼不动杆菌、肺炎克雷伯菌、金黄色葡萄球菌4种菌株为主,对照组和观察组检出率分别为68.63%、42.59%,两组比较差异具有统计学意义(P<0.05)。治疗后,观察组耐药病原菌总清除率为82.61%,显著高于对照组54.81%,差异具有统计学意义(P<0.05)。结论在重症肺炎患者中多数患者为革兰阴性菌耐药菌感染,而在常规西医对症、抗菌治疗基础上加用痰热清注射液能显著提高临床疗效和耐药病原菌总清除率,降低治疗过程中患者耐药菌检出率,值得临床推广。

Objective To analyze the clinical efficacy of Tanreqing Injection on infection rate of drug-resistant bacteria in patients with severe pneumonia. Methods A total of 105 patients with severe pneumonia admitted to Huainan Chaoyang Hospital from January 2018 to September 2020 were selected as the research subjects, and the patients were divided into control group(n=51) and observation group(n=54) according to treatment methods. Patients in the control group was given symptomatic basic treatment, and the observation group were iv administered with Tanreqing Injection intravenously on the basis of the control group, 10 mL was added to 500 mL 5% Glucose injection, once daily. The treatment course was 2 weeks. The clinical efficacy of two groups was observed, and the detection types and detection rates of drug-resistant bacteria, and the total clearance rate of drug-resistant pathogens in two groups were compared. Results After treatment, the total effective rate of observation group was 90.74%, which was significantly higher than 76.47% of control group, and the difference was statistically significant(P < 0.05). The types of drugresistant bacteria detected in two groups were mainly pseudomonas aeruginosa, acinetobacter baumannii, klebsiella pneumonia, and staphylococcus aureus, and the detection rates of control group and observation group were 68.63% and 42.59%, respectively, with statistical significance(P < 0.05). After treatment, the total clearance rate of drug-resistant pathogens in the observation group was82.61%, significantly higher than 54.81% in the control group, with statistical significance(P < 0.05). Conclusion The majority of patients with severe pneumonia are infected by Gram-negative bacteria resistant bacteria, while the addition of Tanreqing Injection on the basis of conventional western medicine symptomatic and antibacterial treatment can significantly improve the clinical efficacy and the total clearance rate of drug-resistant pathogens, and reduce the detection rate of drug-resistant bacteria in patients during treatment, which is worthy of clinical promotion.