摘要
α-葡萄糖苷酶抑制剂能有效降低餐后血糖,为临床一线降糖用药之一。近年来报道了大量新化合物作为α-葡萄糖苷酶抑制剂,不仅可以起到降糖的作用,而且还具有抗溶酶体堆积病、抗病毒、抗菌和抗癌的药效。α-葡萄糖苷酶抑制剂新型化合物按照产出途径主要有微生物代谢产物、天然产物与化学合成产物。就近年来开发的多种类型的α-葡萄糖苷酶抑制剂及其抗癌、抗病毒和抗溶酶体堆积病作用进行了综述,旨在为α-葡萄糖苷酶抑制剂或临床前候选药物提供更好的研究方向。
Alpha-glucosidase inhibitor is one of the first-line antidiabetic medication which could reduce postprandial blood glucose effectively. In recent years, a substantial number of new compounds have been reported as alpha-glucosidase inhibitors, have multiple physiological effects including hypoglycemic effects, anticancer, antiviral, and anti-lysosomal storage disorders effect. The main types of new alpha-glucosidase inhibitor are microbial metabolites, natural products and chemically synthesized products. This review presents the various types of alpha-glucosidase inhibitors developed in recent years and its pharmacological effects, aimed to provide guidance to alpha-glucosidase inhibitors or clinical candidates.
作者
阎成炟
郭崇真
林建阳
YAN Chengda;GUO Chongzhen;LIN Jianyang(Department of Pharmacy,The First Affiliated Hospital of China Medical University,Shenyang 110001,China;College of Pharmaceutical Science,China Medical University,Shenyang 110122,China)
出处
《药物评价研究》
CAS
2021年第2期440-445,共6页
Drug Evaluation Research
基金
国家自然基金青年科学基金资助项目(81302841)
辽宁省高等学校优秀人才支持计划(LJQ2014086)。
关键词
Α-葡萄糖苷酶抑制剂
2型糖尿病
作用机制
药理作用
抗病毒
抗溶酶体堆积病
Alpha-glucosidase
type 2 diabetes mellitus
mechanism of action
pharmacological effect
research progress
antiviral
anti-lysosomal storage disorders
